绝经后女性维生素D营养状况与血脂及骨密度的关系  

Associations of vitamin D,lipid profile and bone mineral density in postmenopausal women

作　　者：庞娜 李胜君 徐春琳[1] PANG Na;LI Shengjun;XU Chunlin(The Second Hospital of Hebei Medical University,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学第二医院,河北石家庄050051

出　　处：《中国骨质疏松杂志》2024年第10期1444-1448,共5页Chinese Journal of Osteoporosis

摘　　要：目的探讨绝经后女性血清25-羟维生素D[25(OH)D]水平与血脂及骨密度(bone mineral density,BMD)的相关性。方法对在河北医科大学第二医院就诊的102名绝经后女性进行横断面调查,收集一般情况、慢性病史、生活方式、血清25(OH)D水平、血脂谱及股骨、腰椎部位骨密度等资料。应用SPSS 28.0软件建立数据库,分析维生素D与血脂谱及骨密度的相关性。结果102名绝经后女性血清25(OH)D平均水平为(18.51±6.02)ng/mL,维生素D缺乏及不足者占96.08%;血清25(OH)D水平与年龄、体重、居住地、日照时间、采血季节有关;25(OH)D水平与总胆固醇(total cholesterol,TC)(Z=8.038,P=0.018)、甘油三酯(triglyceride,TG)(Z=14.318,P<0.001)水平呈负相关,与高密度脂蛋白胆固醇水平(high density lipoprotein cholesterol,HDL-C)(Z=12.150,P=0.002)呈正相关;维生素D与股骨颈骨密度(r=0.501,P=0.001)、股骨转子骨密度(r=0.570,P=0.001)、股骨内部骨密度(r=0.354,P=0.001)、股骨整体骨密度(r=0.404,P=0.001)、Ward’s骨密度(r=0.529,P=0.001)呈正相关;调整年龄、体质量指数(body mass index,BMI)后相关性仍存在。只在L4骨密度(P=0.042)中发现BMI与骨密度呈正相关。结论绝经后女性人群中维生素D缺乏及不足患病率高;维生素D水平充足者有更健康的血脂谱,骨质疏松风险更低。Objective To investigate the associations of 25-hydroxyvitamin D(25(OH)D),lipid profile and bone mineral density(BMD)in postmenopausal women.Methods A cross-section investigation of 102 postmenopausal women who were admitted to the Second Hospital of Hebei Medical University was conducted.Their general condition,chronic medical history,lifestyle,serum 25(OH)D level,blood lipid profile,and bone mineral density in the femur and lumbar spine were collected.SPSS 28.0 software was used to establish a database to analyze the associations of vitamin D and lipid profile and bone mineral density.Results The average content of 25(OH)D in 102 postmenopausal women was(18.51±6.02)ng/mL,and 96.08%of them suffered from vitamin D deficiency or insufficiency.25(OH)D levels were related to age,weight,place of residence,sunshine time,and blood collection season.The level of 25(OH)D was negatively correlated with total cholesterol(TC)(Z=8.038,P=0.018)and triglyceride(TG)(Z=14.318,P<0.001),and positively correlated with the level of high-density lipoprotein cholesterol(HDL-C)(Z=12.150,P=0.002).Vitamin D was positively correlated with bone mineral density of femoral neck(r=0.501,P=0.001),femoral trochanteric(r=0.570,P=0.001),femoral internal(r=0.354,P=0.001),femor(r=0.404,P=0.001),and Ward's(r=0.529,P=0.001).Correlation persisted after adjusting for age and body mass index(BMI).BMI was only positively correlated with bone mineral density of L4(P=0.042).Conclusion Postmenopausal women have a high prevalence of vitamin D deficiency and insufficiency;postmenopausal women with adequate vitamin D have a healthier lipid profile and a lower risk of osteoporosis.

关 键 词：绝经后女性 维生素D 血脂 骨密度 

分 类 号：R681[医药卫生—骨科学] R173[医药卫生—外科学]