H型血管内皮细胞铁死亡对骨稳态影响及相关机制的研究  

Study on the effect of ferroptosis of H-type vascular endothelial cells on bone homeostasis and related mechanisms

作　　者：樊佳煊 曹林忠[1,2] FAN Jiaxuan;CAO Linzhong(Gansu University of Traditional Chinese Medicine,Lanzhou 730000;The Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃中医药大学附属医院,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2024年第10期1449-1454,共6页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(82160859);兰州市科技局项目(2022-3-23)。

摘　　要：H型血管形成与细胞铁死亡作为影响骨稳态的潜在机制,其相互关系在血管生成、骨形成方面逐渐受到关注。H型血管作为血小板-内皮细胞黏附分子(CD_(3)1)、内皮粘蛋白(EMCN)高表达的特殊血管结构,在新骨形成中发挥成血管-成骨耦合作用,促进缺损部位的骨再生;铁死亡是由细胞铁依赖性脂质过氧化物累积驱动的新型细胞死亡方式。近年来内皮细胞(endothelial cells, ECs)铁死亡在相关骨代谢疾病防治中成为研究热点,且相关机制相对成熟,而H型血管ECs铁死亡对骨稳态的研究仍处于初步阶段,因此该综述详细探讨了H型血管ECs铁死亡在血管生成、骨形成方面的作用,有望为深入理解骨稳态提供新的视角,并为开发新的治疗策略提供理论依据。As a potential mechanism affecting bone homeostasis,the relationship between H-type angiogenesis and cell iron death has received increasing attention in the aspects of angiogenesis and bone formation.As a special vascular structure with high expression of platelet-endothelial cell adhesion molecule(CD_(3)1)and endothelial mucin(EMCN),H-type vessels play a coupling role in angiogenesis and osteogenesis during new bone formation,and promote bone regeneration at the site of bone defect.Iron death is a novel cell death mode driven by the accumulation of iron-dependent lipid peroxides.In recent years,iron death of endothelial cells(ECs)has become a hot research topic in the prevention and treatment of related bone metabolic diseases,and the related mechanism is relatively mature,while the research on the effect of iron death of H-type vascular ECs on bone homeostasis is still preliminary.Therefore,this review discussed in detail the role of iron death of H-type vascular ECs on angiogenesis and bone formation.It is expected to provide a new perspective for the in-depth understanding of bone homeostasis and provide a theoretical basis for the development of new treatment strategies.

关 键 词：H型血管 内皮细胞 Nrf2/GPX4信号 铁死亡 骨稳态 

分 类 号：R681[医药卫生—骨科学]