骨膜细胞的生物学特征与组织工程应用  

Biological characteristics and tissue engineering applications of periosteum-derived cells

作　　者：方森 梁钧文 李明春 年稚轩 杨旭东 韵向东[1,2] FANG Sen;LIANG Junwen;LI Mingchun;NIAN Zhixuan;YANG Xudong;YUN Xiangdong(Department of Orthopaedics,the Second Hospital of Lanzhou University,Lanzhou 730030,China;Key Laboratory of Bone and Joint Disease of Gansu Province,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院骨科,甘肃兰州730030 [2]甘肃省骨关节疾病研究重点实验室,甘肃兰州730030

出　　处：《中国骨质疏松杂志》2024年第10期1472-1476,共5页Chinese Journal of Osteoporosis

基　　金：甘肃省自然科学基金项目(22JR11RA051)。

摘　　要：骨膜细胞是一种源自骨膜的多能性干细胞,为再生医学领域提供了潜在的种子细胞来源。近年来,骨膜细胞在基础研究领域取得了显著进展,笔者就骨膜细胞的生物学特征、相关的信号通路、不同的细胞亚群以及影响骨膜细胞成骨的积极和消极因素进行综述,并对其在临床应用以及组织工程领域的发展前景进行了展望。Periosteum-derived cells are a possible source of seed cells for the field of regenerative medicine.They are pluripotent stem cells generated from the periosteum.Significant advancements have been made in the fundamental study of periosteum-derived cells in the last few years.The biological traits of periosteum-derived cells,pertinent signaling pathways,various cell subsets,and positive and negative factors influencing periosteum-derived cells osteogenesis are reviewed in this paper.Their potential for clinical application and development in the field of tissue engineering is also discussed.

关 键 词：骨膜细胞 信号通路 组织工程 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]