血液系统疾病相关骨损害研究进展  

Research progress of bone lesions associated with hematological diseases

作　　者：谭文彬 李佳 刘明玉 路永欣 程雅欣 TAN Wenbin;LI Jia;LIU Mingyu;LU Yongxin;CHENG Yaxin(Department of Endocrinology,the General Hospital of Southern Theater Command of the People’s Liberation Army,Guangzhou 510010,China;The First School of Clinical Medicine,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]中国人民解放军南部战区总医院内分泌科,广东广州510010 [2]南方医科大学第一临床医学院,广东广州510515

出　　处：《中国骨质疏松杂志》2024年第10期1506-1512,共7页Chinese Journal of Osteoporosis

基　　金：国家重点研发计划(2021YFC2501701);广东省中央引导地方科技发展专项基金(KTP20190249)。

摘　　要：血液系统疾病是继发性骨质疏松症(osteoporosis, OP)的重要病因,除了疾病自身致病因素外,相关治疗方案亦对骨代谢产生负面影响,由此导致了此人群中高OP患病率及骨质疏松性骨折风险。然而,其发病机制目前尚未明确,同时缺乏相关诊疗管理建议。因此,本综述分别从致病危险因素与机制、骨损害表现及诊治进展总结了常见血液系统疾病导致继发性OP最新进展,以期为血液系统疾病相关继发性OP的诊疗及管理提供新的思路。Hematological diseases are an important cause of secondary osteoporosis(OP).In addition to the pathogenic factors of the disease itself,the related treatment strategies also have a negative impact on bone metabolism,leading to a high prevalence rate of OP and the risk of osteoporotic fractures in this population.However,its pathogenesis is not clear at present,and there is a lack of relevant suggestion for the diagnosis and treatment.Therefore,this review summarizes the epidemiology,risk factors and mechanisms,manifestations of bone damage,and progress in diagnosis and treatment of common hematological diseases complicated with OP,in order to provide ideas for the diagnosis,treatment,and management of the secondary OP related to hematological diseases.

关 键 词：血液系统疾病 继发性骨质疏松症 发病机制 骨损害 治疗 

分 类 号：R44[医药卫生—诊断学]