骨质疏松症的表观遗传学机制及中药干预作用的研究  

Research in the epigenetic mechanism of osteoporosis and the intervention with traditional Chinese medicine

作　　者：张宇楷 田瀚 张银银 钟业霖 熊诗硕 李启活 郭海威 黄宏兴 李颖 ZHANG Yukai;TIAN Han;ZHANG Yinyin;ZHONG Yelin;XIONG Shishuo;LI Qihuo;GUO Haiwei;HUANG Hongxin;LI Ying(The Third Clinical Medical School,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China;The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510378,China)

机构地区：[1]广州中医药大学第三临床医学院,广东广州510405 [2]广州中医药大学第三附属医院,广东广州510378

出　　处：《中国骨质疏松杂志》2024年第10期1513-1517,1523,共6页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(82374482);广东省自然科学基金(2022A1515011404)。

摘　　要：骨质疏松症是以骨骼微环境中成骨细胞活性降低,骨髓脂肪过度发育以及破骨细胞过度活化为特征的代谢性骨疾病。骨质疏松症发生与多种遗传基因的调控有关,表观遗传学机制发挥重要作用。目前已有多项实验表明中医药通过影响表观遗传机制进而影响骨质疏松症的发生发展。笔者通过对相关文献进行综述,对表观遗传学机制与骨质疏松症的关系以及中医药干预表观遗传学机制防治骨质疏松的研究进行总结性梳理,以期为临床中医药治疗骨质疏松提供一定的思路及借鉴。Osteoporosis is a metabolic bone disease characterized by reduced osteoblast activity in the bone microenvironment,excessive development of bone marrow fat,and excessive activation of osteoclasts.The occurrence of osteoporosis is related to the regulation of many genetic genes.Epigenetic mechanism plays an important role.At present,many experiments have shown that traditional Chinese medicine affects the occurrence and development of osteoporosis by influencing the epigenetic mechanism.By reviewing relevant literature,the author summarizes the relationship between epigenetics and osteoporosis as well as the studies on TCM intervention of epigenetic mechanism to prevent and cure osteoporosis,in order to provide certain ideas and references for clinical TCM treatment of osteoporosis.

关 键 词：骨质疏松症 表观遗传学 中药 

分 类 号：R589.5[医药卫生—内分泌]