骨碎补及其活性成分防治骨质疏松症的作用机制  

The mechanism of rhizoma drynariae and its active components in the prevention and treatment of osteoporosis

作　　者：刘博[1] 丁龙龙 陈志健 张桂鑫 王博 龚春柱 张洪健 刘华忠 廖家俊 LIU Bo;DING Longlong;CHEN Zhijian;ZHANG Guixin;WANG Bo;GONG Chunzhu;ZHANG Hongjian;LIU Huazhong;LIAO Jiajun(Guangzhou University of Chinese Medicine,Guangzhou 510405;Shenzhen Pingle Orthopedic Hospital Affiliated to Guangzhou University of Chinese Medicine,Shenzhen 518010)

机构地区：[1]广州中医药大学,广东广州510405 [2]广州中医药大学附属深圳平乐骨伤科医院,广东深圳518010

出　　处：《中国骨质疏松杂志》2024年第10期1540-1547,共8页Chinese Journal of Osteoporosis

基　　金：深圳市中老年群体骨健康状况流行病学研究项目(2022110);深圳市“医疗卫生三名工程”项目(SZZYSM202311020)。

摘　　要：骨碎补是补肾强骨的经典药材,药理学研究显示其主要活性成分为黄酮类和二氢黄酮类柚皮苷,其在抗骨质疏松、修复骨缺损等方面发挥着积极作用。细胞分子生物学研究提示骨碎补对成骨细胞、破骨细胞和间充质干细胞具有多通路、多因子调节作用,如Wnt/β-catenin、MAPK、OPG/RANKL/RANK、Notch、BMP-Smads、PI3K/Akt等信号通路和TNF-α、白介素-1(IL-1)、白介素-6(IL-6)、雌激素及其受体、组织蛋白酶K(CTSK)等细胞因子。笔者重点综述了中药骨碎补及其提取物防治骨质疏松的信号通路和细胞因子研究进展,旨在为骨碎补的药理药效研究及临床应用提供参考。Rhizoma drynariae is a classic medicine for tonifying kidney and strengthening bone.Pharmacological studies show that its main active components are flavonoids and dihydroflavonoid naringin,which play an active role in anti-osteoporosis and repairing bone defects.Cellular and molecular biological studies suggest that drynaria regulates osteoblasts,osteoclasts,and mesenchymal stem cells through multiple pathways and multiple factors,such as Wnt/β-catenin,MAPK,OPG/RANKL/RANK,Notch,BMP-Smads,PI3K/Akt,and cytokines such as TNF-α,interleukin-1(IL-1),interleukin-6(IL-6),and estrogen and its receptor,Cathepsin K(CTSK).This paper focuses on the research progress of signal pathways and cytokines of rhizoma drynariae and its extracts in the prevention and treatment of osteoporosis,in order to provide reference for the pharmacological and pharmacological research and clinical application of drynaria.

关 键 词：骨质疏松症 骨碎补 骨碎补总黄酮 柚皮苷 成骨细胞 破骨细胞 间充质干细胞 

分 类 号：R285[医药卫生—中药学]