氨氯地平贝那普利片(Ⅱ)治疗老年人高血压的疗效及安全性评价  

Efficacy and safety of amlodipine besylate and benazepril hydrochloride tablets(Ⅱ)in the treatment of hypertension in older adult patients

作　　者：王睿 洪飞 Wang Rui;Hong Fei(Department of Cardiovascular Medicine,The Jinqiu Hospital of Liaoning Province,Shenyang 110000,Liaoning Province,China)

机构地区：[1]辽宁省金秋医院心血管内科,沈阳110000

出　　处：《中国基层医药》2024年第10期1502-1506,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察氨氯地平贝那普利片(Ⅱ)治疗老年原发性高血压患者的疗效及安全性。方法选取辽宁省金秋医院2023年7—12月门诊及住院治疗的2级以上老年原发性高血压患者100例,给予氨氯地平贝那普利片(Ⅱ)治疗,1片/d,持续治疗8周,观察血压达标时间及达到稳定血药浓度的时间。结果100例患者中,2级高血压60例,3级高血压40例;男53例,年龄(76.41±6.70)岁;女47例,年龄(77.34±7.60)岁;2级高血压患者治疗后总达标率为95.0%(57/60),高于3级高血压患者的80.0%(32/40)(χ^(2)=4.09,P=0.043)。2级高血压患者平均血压达标时间为7.5 d,平均有效时间为4.5 d,3级高血压患者平均达标时间为13.2 d,平均有效时间为6.1 d。100例患者治疗第1、2、4、8周的收缩压、舒张压差异均有统计学意义(均P<0.001)。2级高血压患者治疗第1、2周及第4周血压达标率均明显高于3级高血压患者(均P<0.05)。2级高血压患者治疗第1周有效率明显高于3级高血压患者(χ^(2)=7.16,P=0.007)。2级高血压与3级高血压患者不良反应发生率差异无统计学意义(χ^(2)=0.22,P=0.640)。结论氨氯地平贝那普利片(Ⅱ)对老年高血压患者降压效果显著,可明显改善患者血压,且不良反应发生率较低。Objective To investigate the efficacy and safety of amlodipine besylate and benazepril hydrochloride tablets(Ⅱ)in the treatment of primary hypertension in older adult patients.Methods A total of 100 older adult patients with primary hypertension of grade 2 or higher who received outpatient and inpatient treatment at The Jinqiu Hospital of Liaoning Province from July to December 2023 were included in this study.They were treated with amlodipine besylate and benazepril hydrochloride tablets(Ⅱ),1 tablet per day,for 8 successive weeks.The time to achieve target blood pressure and the time to reach stable drug concentration in the blood were monitored.Results Among the 100 patients,there were 60 with grade 2 hypertension and 40 with grade 3 hypertension.Of the patients,53 were male,with an average age of(76.41±6.70)years,and 47 were female,with an average age of(77.34±7.60)years.The overall target achievement rate for patients with grade 2 hypertension after treatment was 95.0%(57/60),which was significantly higher than the 80.0%(32/40)for patients with grade 3 hypertension(χ^(2)=4.09,P=0.043).The average time to achieve target blood pressure for patients with grade 2 hypertension was 7.5 days,with an average effective duration of 4.5 days.The average to achieve target blood pressure for patients with grade 3 hypertension was 13.2 days,with the average effective duration of 6.1 days.The differences in systolic and diastolic blood pressure among the 100 patients at 1,2,4,and 8 weeks of treatment were statistically significant(all P<0.001).The blood pressure achievement rates for patients with grade 2 hypertension at 1,2,and 4 weeks were significantly higher than those for patients with grade 3 hypertension(all P<0.05).At 1 week of treatment,the effective rate for patients with grade 2 hypertension was significantly higher than that for patients with grade 3 hypertension(χ^(2)=7.16,P=0.007).There was no statistically significant difference in the incidence of adverse reactions between patients with grade 2 and g

关 键 词：高血压 药物疗法 抗高血压药 氨氯地平 血压 药物相关性副作用和不良反应 老年人 

分 类 号：R544.1[医药卫生—心血管疾病]