瘢痕性气道再狭窄的治疗和预防研究进展  

Advances in the treatment and prevention of cicatricial airway stenosis

作　　者：雷思源 杨雨晨 高永恒 金发光 Lei Siyuan;Yang Yuchen;Gao Yongheng;Jin Faguang(Department of Respiratory and Critical Care Medicine,Tangdu Hospital,Air Force Medical University,Xi'an 710038,China;Department of Chinese Medicine,Tangdu Hospital,Air Force Medical University,Xi'an710038,China)

机构地区：[1]空军军医大学唐都医院呼吸与危重症医学科,西安710038 [2]空军军医大学唐都医院中医科,西安710038

出　　处：《国际呼吸杂志》2024年第9期1082-1089,共8页International Journal of Respiration

基　　金：国家公益性行业科研专项(201402024)。

摘　　要：良性气道狭窄显著降低了患者的生活质量。随着介入肺脏学的进步,利用支气管镜的介入治疗已经成为首选方案,其因创伤小和见效快等优点受到临床医生的青睐。然而,此种治疗也不可避免地对气管造成一定损伤,可能导致组织修复过程中出现瘢痕性再狭窄,进而需要患者接受进一步的手术治疗。因此,如何有效降低再狭窄的发生率或延长其发生时间,已经成为临床面临的一个重大挑战。本文综述了防治良性气道狭窄介入治疗后瘢痕性再狭窄的策略,包括采用合适的介入治疗技术和术后使用抗瘢痕药物。这些措施有助于降低瘢痕性气道再狭窄的风险,从而显著提升患者的生活质量。Benign airway stenosis significantly reduces the quality of life of affected patients.With great strides made on the interventional pulmonology,an interventional therapy using bronchoscopy is preferred due to the minimal invasiveness and rapid efficacy.However,it inevitably damage the airways,leading to scar-induced restenosis during tissue repair and further demands for surgery.Therefore,how to effectively reduce the incidence of scar-induced restenosis or delay the occurrence of restenosis has become a major clinical challenge.The present study reviewed therapeutic strategies for preventing and treating scar-induced restenosis after an interventional treatment of benign airway stenosis,including the use of appropriate interventional techniques and postoperative use of antiscarring medications.These measures can help reduce the risk of scar-induced restenosis and thus significantly improve the quality of life of affected patients.

关 键 词：气管狭窄 介入治疗 瘢痕性狭窄 预防 

分 类 号：R562.12[医药卫生—呼吸系统]