内质网应激对睾丸间质细胞中睾酮合成影响的研究进展  

Research Progress on the Effect of Endoplasmic Reticulum Stress on Testosterone Synthesis in the Leydig Cells

作　　者：李敬轩 龙城 齐晓龙[1] LI Jingxuan;LONG Cheng;QI Xiaolong(College of Animal Science and Technology,Beijing Unversity of Agriculture,Beijing 102206,China)

机构地区：[1]北京农学院动物科学技术学院,北京102206

出　　处：《中国畜牧兽医》2024年第11期4722-4731,共10页China Animal Husbandry & Veterinary Medicine

基　　金：国家自然科学基金(32472955);国家自然科学基金青年基金(32302795);北京农学院科技创新“火花行动”支持计划(BUA-HHXD2022008);北京农学院青年教师科研创新能力提升计划(QJKC2022026);北京市教育委员会科学研究计划项目(KM202310020008)。

摘　　要：内质网是具有多种功能的细胞器,参与物质运输,在蛋白质修饰加工、脂质与甾体类激素的合成、细胞应激以及维持钙稳态等生物活动中发挥重要作用。当内质网上错误折叠或未折叠蛋白过度堆积会引起内质网应激反应,无法调节时则会启动细胞凋亡程序。睾丸间质细胞是睾酮合成的主要场所,通过一系列合成酶将胆固醇转化为睾酮,对于维持动物繁殖性能至关重要。近年来有研究显示,在雄性动物睾丸间质细胞合成睾酮过程中,常包含内质网应激和未折叠蛋白反应,通过调控不同的信号通路导致细胞凋亡,影响睾酮合成。而目前对于内质网应激对睾酮合成影响的具体机制尚不明确。作者综述了在雄性动物睾丸间质细胞中,内质网应激介导不同细胞凋亡途径、氧化损伤以及钙离子途径对睾酮合成的影响及可能的分子机制,以期为通过调节内质网应激从而提高睾酮合成提供新思路。The endoplasmic reticulum is a multifunctional organelle that participates in material transport and plays an important role in biological activities such as protein modification and processing,synthesis of lipids and steroid hormones,cellular stress,and maintenance of calcium homeostasis.When there is an excessive accumulation of misfolded or unfolded proteins on the endoplasmic reticulum,it can cause an endoplasmic reticulum stress response that cannot be regulated,leading to the initiation of cell apoptosis.Leydig cells are the primary site of testosterone synthesis,converting cholesterol into testosterone through a series of enzymes,which is crucial for maintaining animal reproductive performance.Recent studies have shown that during the process of testosterone synthesis in male animal Leydig cells,endoplasmic reticulum stress,and the unfolded protein response are often involved,leading to cell apoptosis through different signaling pathways and affecting testosterone synthesis.However,the specific mechanisms by endoplasmic reticulum stress influences testosterone synthesis remain unclear.The authors reviewed the effects and possible molecular mechanisms of endoplasmic reticulum stress mediated apoptosis pathways,oxidative damage,and calcium signaling pathways on testosterone synthesis in male animal Leydig cells,in order to provide new insights into improving testosterone synthesis by regulating endoplasmic reticulum stress.

关 键 词：内质网应激 睾丸间质细胞 睾酮 细胞凋亡 

分 类 号：S814.1[农业科学—畜牧学]