纳布啡联合环泊酚或丙泊酚在老年患者无痛胃肠镜中应用效果分析  

Application effect of nalbuphine combined with ciprofol or propofol in painless gastroscopy in elderly patients

作　　者：姚一鹏 朱旭[1] 游卓玉[1] YAO Yipeng;ZHU Xu;YOU Zhuoyu(Department of Anesthesiology,Xiamen Traditional Chinese Medicine Hospital,Xiamen 361000,China)

机构地区：[1]厦门市中医院麻醉科,福建厦门361000

出　　处：《广州医药》2024年第10期1152-1158,1204,共8页Guangzhou Medical Journal

摘　　要：目的对比纳布啡联合环泊酚、纳布啡联合丙泊酚应用于老年患者无痛胃镜中的效果。方法选取厦门市中医院2021年10月至2022年10月收治的180例老年患者(均行无痛胃肠镜检查)为研究对象,按照随机数表法分组,其中A组90例患者给予纳布啡联合环泊酚,B组90例患者给予纳布啡联合丙泊酚,对比两组患者麻醉相关指标、血流动力学、围术期不良反应。结果两组患者诱导量、诱导时间、追加次数、总追加量、苏醒时间、恢复室停留时间对比差异均无统计学意义(t=1.486、0.830、1.157、0.941、0.906、1.403,均P>0.05);重复测量方差分析结果显示,分组因素间收缩压(SBP)(F=30.019,P<0.001)、心率(HR)(F=282.057,P<0.001)、SpO2(F=64.518,P<0.001)、;时间因素SBP(F=21.780,P<0.001)、HR(F=345.118,P<0.001)、SpO2(F=41.762,P<0.001);分组与时间交互时间因素SBP(F=12.941,P<0.001)、HR(F=193.295,P<0.001)、SpO2(F=13.546,P<0.001),差异均有统计学意义。折线图直观显示,A组患者SBP、HR、SpO2、较B组低。;A组患者围术期不良反应发生率(20.00%)低于B组患者(56.67%)(χ^(2)=25.593,P<0.001)。结论两种麻醉方案应用于老年无痛胃肠镜,麻醉效果相近,环泊酚复合纳布啡血流动力学更稳定,且围术期不良反应的发生率较低。Objective To compare the effects of nalbuphine combined with ciprofol and nalbuphine combined with propofol on painless gastroscopy in elderly patients.Methods A total of 180 elderly patients(all underwent painless gastroscopy)admitted to Xiamen Traditional Chinese Medicine Hospital from October 2021 to October 2022 were selected as the study subjects.They were randomly divided into groups using a random number table method.Among them,90 patients in Group A were given a combination of nalbuphine and ciprofol,while 90 patients in Group B were given a combination of nalbuphine and propofol.Anesthesia related indicators,hemodynamics,and perioperative adverse reactions were compared between the two groups.There was no statistically significant difference in the induction amount,induction time,number of additional times,total additional amount,awakening time,and recovery room stay time between the two groups of patients(t=1.486,0.830,1.157,0.941,0.906,1.403,all P>0.05).The results of repeated measures analysis of variance showed that there were statistically significant differences among the grouping factors,including SBP(F=30.019,P<0.001),HR(F=282.057,P<0.001),SpO_(2)(F=64.518,P<0.001),time factors SBP(F=21.780,P<0.001),HR(F=345.118,P<0.001),SpO_(2)(F=41.762,P<0.001),and interaction factors SBP(F=12.941,P<0.001),HR(F=193.295,P<0.001),and SpO_(2)(F=13.546,P<0.001).The line chart visually shows that the SBP,HR,SpO_(2)of Group A patients were lower than those of Group B.The incidence of perioperative adverse reactions in Group A patients(20.00%)was lower than that in Group B patients(56.67%)(χ^(2)=25.593,P<0.001).Conclusions The two anesthesia regimens used for elderly painless gastroscopy have similar anesthesia effects,with more stable hemodynamics of ciprofol combined with nalbuphine,and a lower incidence of perioperative adverse reactions.

关 键 词：纳布啡 环泊酚 丙泊酚 无痛胃肠镜 

分 类 号：R614[医药卫生—麻醉学]