复方甘草口服液联合泼尼松治疗特发性肺间质纤维化急性加重期患者的疗效及安全性研究  

Study on the efficacy and safety of compound licorice oral liquid combined with prednisone in the treatment of patients with acute exacerbation of idiopathic pulmonary interstitial fibrosis

作　　者：刘丽 张明 任建兵 米奇珍 闫有鹏 LIU Li;ZHANG Ming;REN Jianbing;MI Qizhen;YAN Youpeng(Zhangye Second People’s Hospital of Traditional Chinese Medicine,Rheumatism immunity a branch of traditional Chinese medicine Zhangye 734000,China)

机构地区：[1]张掖市第二人民医院风湿免疫中医一科,甘肃张掖734000

出　　处：《广州医药》2024年第10期1177-1182,共6页Guangzhou Medical Journal

摘　　要：目的探讨复方甘草口服液联合泼尼松治疗特发性肺间质纤维化急性加重期患者的疗效。方法选取张掖市第二人民医院2020年1月—2023年10月收治的128例特发性肺间质纤维化急性加重期患者,应用随机数字表法分为两组,每组各64例。对照组采取泼尼松治疗,观察组采取复方甘草口服液联合泼尼松治疗。对比其临床疗效,治疗前后血清肺纤维化指标及炎症因子水平,最后对比其不良反应发生率。结果观察组总有效率93.75%,高于对照组的79.69%(χ^(2)=5.490,P=0.019);治疗前两组层黏连蛋白(LN)、Ⅲ型前胶原肽(PC-Ⅲ)、透明质酸(HA)对比差异无统计学意义(P>0.05),治疗后两组患者LN、PC-Ⅲ、HA均降低,观察组[(89.25±7.61)μg/L;(68.33±7.68)mg/L;(81.53±8.54)μg/L]低于对照组[(96.17±8.34)μg/L;(75.68±8.25)mg/L;(95.68±9.25)μg/L],对比差异有统计学意义(t_(1)=4.903,P_(1)<0.001;t_(2)=5.217,P_(2)<0.001;t_(3)=8.992,P_(3)<0.001);治疗前两组患者肿瘤坏死因子-α(TNF-α)、白细胞介素-4(IL-4)、IL-10、转化生长因子(TGF-β1)对比差异无统计学意义(P>0.05),治疗后两组TNF-α、IL-4、IL-10、TGF-β1水平降低,观察组[(61.94±8.24)ng/L;(4.43±1.17)ng/mL;(65.49±13.24)g/L;(114.73±13.12)pg/mL]低于对照组[(75.52±9.43)ng/L;(6.31±1.28)ng/mL;(79.27±9.38)g/L;(147.76±15.46)pg/mL],对比差异有统计学意义(t_(1)=8.675,P1<0.001;t_(2)=8.673,P_(2)<0.001;t_(3)=6.794,P_(3)<0.001;t_(4)=13.032,P4<0.001);两组不良反应发生率对比差异无统计学意义(7.81%vs 6.25%,χ^(2)=0.120,P=0.730)。结论复方甘草口服液联合泼尼松治疗特发性肺间质纤维化急性加重期疗效显著,可辅助延缓患者肺纤维化发展进程,减轻机体炎症反应,安全性较高。Objective To investigate the efficacy of compound licorice oral liquid combined with prednisone in patients with acute exacerbations of idiopathic pulmonary interstitial fibrosis.Methods A total of 128 patients with acute exacerbation of idiopathic pulmonary interstitial fibrosis admitted to Zhangye Second People’s Hospital from January 2020 to October 2023 were divided into two groups by random number table method,with 64 patients in each group.The control group received prednisone treatment,while the observation group received compound licorice oral liquid combined with prednisone treatment.Compare its clinical efficacy,serum pulmonary fibrosis indicators and inflammatory factor levels before and after treatment,and finally compare its incidence of adverse reactions.Results The total response rate in the observation group was 93.75%,which was higher than the 79.69%in the control group(χ^(2)=5.490,P=0.019).There was no difference between the two groups of LN,PC-III,and HA(P>0.05),LN,PC-III and HA were decreased in both groups,while the observation group[(89.25±7.61)μg/L;(68.33±7.68)mg/L;(81.53±8.54)μg/L]was lower than the control group[(96.17±8.34)μg/L;(75.68±8.25)mg/L;(95.68±9.25)μg/L],the contrast difference was statistically significant(t_(1)=4.903,P_(1)<0.001;t_(2)=5.217,P_(2)<0.001;t_(3)=8.992,P_(3)<0.001).There was no difference in TNF-α,IL-4,IL-10,and TGF-β1 between the two groups before treatment(P>0.05),lower levels of TNF-α,IL-4,IL-10,and TGF-β1 in the two patient groups after treatment,the observation group[(61.94±8.24)ng/L;(4.43±1.17)ng/mL;(65.49±13.24)g/L;(114.73±13.12)pg/mL]was lower than the control group[(75.52±9.43)ng/L;(6.31±1.28)ng/mL;(79.27±9.38)g/L;(147.76±15.46)pg/mL],the contrast difference was statistically significant(t_(1)=8.675,P_(1)<0.001;t_(2)=8.673,P_(2)<0.001;t_(3)=6.794,P_(3)<0.001;t_(4)=13.032,P_(4)<0.001).There was no difference in the incidence of adverse effects between the two groups(7.81%vs 6.25%,χ^(2)=120,P=0.730).Conclusions The combination of com

关 键 词：复方甘草口服液 泼尼松 特发性肺间质纤维化 急性加重期 不良反应 炎症因子 

分 类 号：R563[医药卫生—呼吸系统]