重楼皂苷凝胶剂制备工艺研究  

Study on the Preparation Technology of Gelling Agent Zonoside

作　　者：王志禹 孙晴 赵杰扬 危永芳 Wang Zhiyu;Sun Qing;Zhao Jeiyang;Wei Yongfang(College of Pharmacy,Changsha Medical University,Hunan Provincial Key Laboratory of New Drug Preparation Research and Development,Hunan Province“Double First-class”Application Characteristic Discipline-Pharmacy,Shangsha 410219,China;School of Stomatology,Changsha Medical University,Shangsha 410219,China)

机构地区：[1]长沙医学院药学院、新型药物制剂研发湖南省重点实验室、湖南省“双一流”应用特色学科-药学,长沙410219 [2]长沙医学院口腔医学院,长沙410219

出　　处：《黑龙江科学》2024年第20期87-90,共4页Heilongjiang Science

基　　金：2020年国家级大学生创新创业项目,教高司函[2020]13号S202010823016。

摘　　要：通过体外透皮实验和处方优化等手段制备一种以重楼为主要成分的凝胶剂,对其载药量、质量控制、透皮吸收等进行全面考察。以卡波姆-940、丙二醇、PEG-400、薄荷脑、樟脑为辅料,采用冷溶法制备凝胶剂;通过载药量考察及质量考察对其配比进行优化。结果表明,最优处方配比为卡波姆-940∶丙二醇:PEG-400∶薄荷脑∶樟脑=1∶2∶4∶1.44∶2.34(质量比),按此配比所得凝胶剂质地均匀,黏稠度高,通过该工艺制备的重楼皂苷凝胶剂具有良好的成形性、可涂抹性,相对药理作用明显,胶粒分散均匀。By means of in vitro transdermal experiment and prescription optimization,the study prepares a gel with Zhonou as the main component,and investigates its drug loading,quality control and transdermal absorption,etc.The study takes carbom-940,propylene glycol,PEG-400,menthol and camphor as excipients,prepares the gel by cold solution method,and optimizes the ratio through the investigation of drug loading and quality.The results show that the optimal formulation ratio is carbom-940:propylene glycol:PEG-400:menthol:camphor=1:2:4:1.44:2.34(mass ratio).The gel obtained by this ratio is uniform in texture and high in viscosity.The gel prepared by this process has good formability,spread ability,obvious relative pharmacological action and uniform dispersion of colloidal particles.

关 键 词：重楼皂苷 凝胶剂 载药量考察 质量考察 

分 类 号：R284[医药卫生—中药学] TQ461[医药卫生—中医学]