苯环喹溴铵鼻喷剂与糠酸莫米松鼻喷雾剂治疗中-重度变应性鼻炎患者的疗效比较  

Comparison of therapeutic effect of phenciquine bromide nasal spray and mometasone furoate nasal spray in the treatment of moderate to severe allergic rhinitis

作　　者：李海洋 吴玉彬 李凤 王涛 马伟 LI Haiyang;WU Yubin;LI Feng;WANG Tao;MA Wei(Department of Otolaryngology,Daxing Teaching Hospital,Capital Medical University,Beijing 102600,China)

机构地区：[1]首都医科大学大兴教学医院耳鼻咽喉科,北京102600

出　　处：《中国耳鼻咽喉颅底外科杂志》2024年第5期23-26,共4页Chinese Journal of Otorhinolaryngology-skull Base Surgery

摘　　要：目的比较中-重度变应性鼻炎(AR)患者应用苯环喹溴铵鼻喷剂与糠酸莫米松鼻喷雾剂的临床疗效。方法选取2022年5月-2023年8月就诊的200例中-重度AR患者,按照随机数字表法进行分组,对照组100例采用糠酸莫米松鼻喷雾剂治疗,研究组100例采用苯环喹溴铵鼻喷剂治疗,对比两组临床疗效、鼻部症状评分、生活质量及其不良反应。结果研究组总有效率高于对照组(93.00%vs 82.00%,χ^(2)=5.531,P=0.018);两组治疗4周后鼻塞、打喷嚏、鼻痒、流涕及鼻炎生活质量问卷(RQLQ)各项评分较同组治疗前均降低,且研究组降低更明显(P<0.05);两组不良反应发生率无统计学差异(7.00%vs 3.00%,P>0.05)。结论中-重度AR患者应用苯环喹溴铵鼻喷剂与糠酸莫米松鼻喷雾剂治疗,均可取得良好疗效,相比较而言,前者疗效更好,可快速改善患者症状,有利于提高生活质量。Objective To compare the clinical effect of bencycloquinium bromide nasal spray and mometasone furoate nasal spray in patients with moderate to severe allergic rhinitis(AR).Methods Two hundred patients with moderate to severe AR treated from May 2022 to August 2023 were selected and divided into groups according to random number table method.One hundred patients in the control group were treated with mometasone furoate nasal spray,and 100 in the study group were treated with phenylcycloquine ammonium bromide nasal spray.The clinical efficacy,nasal symptom scores,quality of life and adverse reactions of the two groups were compared.Results The total effective rate of the study group was higher than that of the control group(93.00%vs 82.00%,χ^(2)=5.531,P=0.018).The scores of nasal congestion,sneezing,nasal itching,runny nose,and rhinitis quality of life questionnaire(RQLQ)after 4 weeks of treatment in both groups were lower than those before treatment,and the decrease was more significant in the study group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(7.00%vs 3.00%,P>0.05).Conclusions Both phencycliquium bromide nasal spray and mometasone furoate nasal spray can achieve good therapeutic effect in the treatment of moderate to severe AR.In comparison,the former has better effect,can rapidly improve the symptoms of patients,and is conducive to improving the quality of life.

关 键 词：中-重度变应性鼻炎 苯环喹溴铵鼻喷剂 糠酸莫米松鼻喷雾剂 治疗效果 生活质量 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]