血管活性肠肽及其受体CRTH2在2型炎症疾病中的作用研究  

Research advances in the role of vasoactive intestinal peptide and its receptor CRTH2 in type 2 inflammatory diseases

作　　者：李睿颖 卢磊 薛金梅[2] LI Ruiying;LU Lei;XUE Jinmei(Shanxi Medical University,Taiyuan 030000,China;Department of Otolaryngology Head and Neck Surgery,the Second Hospital of Shanxi Medical University,Shanxi Provincial Key Laboratory for NeuroImmunity Research on Airway Inflammatory Diseases,Shanxi Provincial Key Laboratory for Rapid Diagnosis and Precise Treatment of Airway Allergic Diseases,Taiyuan 030001,China)

机构地区：[1]山西医科大学,山西太原030000 [2]山西医科大学第二医院耳鼻咽喉头颈外科、山西省气道炎性疾病神经免疫研究省级重点培育实验室气道过敏性疾病快速诊断及精准治疗山西省重点实验室,山西太原030001

出　　处：《中国耳鼻咽喉颅底外科杂志》2024年第5期115-121,共7页Chinese Journal of Otorhinolaryngology-skull Base Surgery

基　　金：国家自然科学基金面上项目(81970865);“四个一批”科技兴医创新计划项目(2022XM06);山西省留学人员科技活动择优资助项目(20240049);山西省基础研究计划(青年项目:202203021212051);山西医科大学第二医院青年基金(202202-2)。

摘　　要：2型炎症是以辅助性T细胞(Th)2、2型固有淋巴样细胞(ILC2)及相关细胞因子,如白细胞介素(IL)-4、IL-5、IL-13、IL-31等为主所介导的炎症,给人们的工作和生活带来沉重负担,亟需找到有效的治疗方法。研究表明,血管活性肠肽(VIP)与2型炎症的发生发展密切相关。VIP是一种广泛分布的神经肽,在神经-免疫轴中发挥了重要作用。Th2表达趋化受体-同源分子(CRTH2)是VIP的受体之一,在2型炎症疾病中表达异常增高,其主要通过激活Th2、ILC和诱导嗜酸性粒细胞分泌前列腺素(PG)D2,进一步促进Th2型细胞因子分泌增多,使得Th2分化增强来参与2型炎症反应。本文综述了VIP及其受体CRTH2在2型炎症疾病中的作用机制及其治疗的研究进展,希望为相关疾病的诊治提供新的理论依据和思路。Type 2 inflammation is mainly mediated by Th2(T helper 2 cells,Th2),type 2 inherent lymphoid cells(ILC2)and related cytokines such as interleukin(IL)-4,IL-5,IL-13,IL-31,etc.Type 2 inflammation brings a heavy burden to people’s work and life,and it is urgent to find effective treatment methods.Studies have shown that vasoactive intestinal peptide(VIP)is closely related to the occurrence and development of type 2 inflammation.VIP is a widely distributed neuropeptide that plays an important role in the neuro-immune axis.The chemoattractant receptor-homologous molecule expressed on Th2(CRTH2)is one of the receptors of VIP,which is abnormally elevated in type 2 inflammatory diseases.It mainly activates Th2 and ILC2 cells and induces eosinophils to secrete Prostaglandin D2(PGD2),which further promotes the secretion of Th2 cytokines and enhances the differentiation of Th2 cells to participate in type 2 inflammatory.The paper reviews the research progress on the mechanism of action and treatment of VIP and its receptor CRTH2 in type 2 inflammatory diseases.It is hoped to provide new theoretical basis and ideas for the diagnosis and treatment of the related disease.

关 键 词：变应性鼻炎 血管活性肠肽 Th2表达趋化受体-同源分子 2型炎症 靶向治疗 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]