参芎葡萄糖注射液联合鼠神经生长因子治疗新生儿缺氧缺血性脑病的临床研究  

Clinical Research of Shenxiong Glucose Injection Combined with Mouse Nerve Growth Factor in the Treatment of HIE Neonates

作　　者：黄丽 杨依 HUANG Li;YANG Yi(Department of Neonatology,the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi Hubei 445000,China)

机构地区：[1]恩施土家族苗族自治州中心医院新生儿科,湖北恩施445000

出　　处：《联勤军事医学》2024年第8期694-697,714,共5页Military Medicine of Joint Logistics

摘　　要：目的 探讨参芎葡萄糖注射液(Shenxiong glucose injection,SGI)联合鼠神经生长因子(mouse nerve growth factor,mNGF)治疗新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)的疗效及对血清髓鞘碱性蛋白(myelin basic protein,MBP)和神经生长因子(nerve growth factor,NGF)水平的影响。方法 选择2021-08/2023-11月收治的HIE患儿120例,利用分层随机化分组法将其分为对照组和观察组,每组60例。对照组使用SGI进行治疗,观察组使用SGI+mNGF进行治疗。观察两组患者的治疗效果、运动表现测试(test of infant motor performance,TIMP)评分、行为神经测定(neonatal behavioral neurological assessment,NBNA)评分、血气指标[乳酸(lactic acid,Lac)、酸碱度(pondus hydrogenii,pH)、二氧化碳分压(partial pressure of carbon dioxide,PaCO_(2))、碱剩余(base excess,BE)、氧分压(partial pressure of oxygen,PaO_(2))]、MBP及NGF水平,同时观察用药期间两组患儿不良反应发生情况。结果 观察组患儿治疗总有效率(91.67%)显著高于对照组(75.00%),差异有统计学意义(P<0.05)。两组患儿pH、PaO_(2)、BE、TIMP、NBNA和NGF在治疗后均显著升高,且观察组高于对照组,差异均有统计学意义(P均<0.05);PaCO_(2)、Lac、MBP水平均显著降低,且观察组低于对照组,差异均有统计学意义(P均<0.05);两组患儿不良反应发生率差异无统计学意义(P>0.05)。结论 使用SGI联合mNGF治疗新生儿HIE具有显著疗效,且可以改善患儿血液氧合功能,提高其运动能力,在降低MBP水平的同时,还可提高NGF水平,对修复新生儿神经功能损伤效果显著。Objective To explore the efficacy of Shenxiong glucose injection(SGI) combined with mouse nerve growth factor(mNGF) in the treatment of neonatal hypoxic-ischemic encephalopathy(HIE) and its influence on serum myelin basic protein(MBP) and nerve growth factor(NGF) levels.Methods A total of 120 neonates with HIE in the hospital from August 2021 to November 2023 were selected and randomly divided into control group and observation group by stratified randomization grouping method,with 60 neonates in each.The control group was treated with SGI,while the observation group was treated with SGI+mNGF.The therapeutic effect,test of infant motor performance(TIMP) score,neonatal behavioral neurological assessment(NBNA) score,blood gas indicators [lactic acid(Lac),pondus hydrogenii(pH),partial pressure of carbon dioxide(PaCO_2),base excess(BE),partial pressure of oxygen(PaO_2)],MBP and NGF levels of the patients were observed between two groups,and the differences in adverse events were observed between two groups during medication.Results The total effective rate of treatment in observation group(91.67%) was significantly higher than that in control group(75.00%),the difference was statistically significant(P<0.05).The pH,PaO_2,BE,TIMP,NBNA and NGF in two groups were significantly increased after treatment,and the indicators in observation group were higher than those in contrl group,the difference was statistically significant(all P<0.05);the levels of PaCO_2,Lac and MBP in two groups decreased significantly,and the indicators in control group was lower than those in control group,the difference was statistically significant(all P<0.05);there was no significant difference in the total incidence rate of adverse events between two groups(P>0.05).Conclusion The application of SGI combined with mNGF in the treatment of neonatal HIE has significant efficacy,which can improve the blood oxygenation function,enhance the motor ability,reduce the level of serum MBP and improve the NGF level of the neonates,and it has a significant e

关 键 词：新生儿 缺氧缺血性脑病 参芎葡萄糖注射液 鼠神经生长因子 血清髓鞘碱性蛋白 神经生长因子 

分 类 号：R722.19[医药卫生—儿科]