二尖瓣钳夹术后发生后负荷不匹配的危险因素分析  

R541Clinical characteristics of patients with MitraClip operation and predictors for the occurrence of afterload mismatch

作　　者：庄晓东[1] 文晗 黄日华 徐兴浩 张绍钊 熊振宇 廖新学[1] ZHUANG Xiao-dong;WEN Han;HUANG Ri-hua;XU Xing-hao;ZHANG Shao-zhao;XIONG Zhen-yu;LIAO Xin-xue(Department of Cardiology,the First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China)

机构地区：[1]中山大学附属第一医院心血管内科,广东广州510080

出　　处：《中国介入心脏病学杂志》2024年第10期562-568,共7页Chinese Journal of Interventional Cardiology

基　　金：国家自然科学基金项目(82070384、82370358)。

摘　　要：目的 探讨二尖瓣钳夹术(MitraClip)后发生后负荷不匹配(AM)的相关危险因素,以早期评估手术风险。方法 本研究为回顾性队列研究,纳入2021年12月至2023年12月在中山大学附属第一医院心血管内科住院的48例因重度二尖瓣反流(MR)行MitraClip手术患者。收集手术患者术前的临床资料、实验室检查、以及术前和术后的彩色多普勒超声心动图检查结果。根据是否发生AM[患者左心室射血分数(LVEF)术后相较于术前减少15%及以上,即dLVEF≤–15%]将患者分为AM组和非AM组。采用单因素及多因素Logistic回归分析MitraClip术患者发生术后AM的相关因素。结果 在48例接受了MitraClip手术的患者中,有14例(29.2%)在术后发生了AM,即AM组。非AM组其整体LVEF较术前有所提高,差异无统计学意义,而AM组较术前有所降低,差异有统计学意义(P=0.019);无论是AM组还是非AM组,患者整体的左心室舒张末期内径(LVEDd)、左心室舒张末期容积指数(LVEDVi)均较术前减小,但差异均无统计学意义(均P>0.05)。单因素Logistic回归分析显示,C反应蛋白(OR 1.98,95%CI 1.02~3.83)、血小板计数(OR 2.22,95%CI 1.08~4.53)、全身免疫炎症指数(OR 1.96,95%CI 1.03~3.71)与MitraClip手术患者发生AM风险增高相关(均P<0.05),而术前右心房内径较大(OR 0.35,95%CI 0.13~0.93)、合并中重度三尖瓣反流(OR 0.19,95%CI0.05~0.81)的患者,术后发生AM的风险更低(均P<0.05),且在矫正了年龄及性别变量后,这种相关性依然存在。结论 C反应蛋白、血小板水平、全身免疫炎症指数升高与MitraClip手术患者发生AM风险增高相关,而术前右心房内径较大、合并中重度三尖瓣反流的患者,术后发生AM的风险更低。Objective To explore the risk factors related to afterload mismatch(AM)after transcatheter mitral valve repair(MitraClip).Methods This was a retrospective cohort study.48 patients hospitalized in the Department of Cardiovascular Medicine,the First Affi liated Hospital of Sun Yat-sen University from December 2021 to December 2023,who underwent MitraClip due to severe mitral regurgitation(MR)were included.Preoperative clinical data,laboratory tests,and preoperative and postoperative color Doppler echocardiographic examination results of surgical patients were collected.AM was defi ned as the left ventricular ejection fraction(LVEF)decreased by 15%or more after surgery compared with the one before(dLVEF≤-15%).Patients were divided into AM group and non-AM 10group according to whether afterload mismatch occurred.Univariate and multivariate logistic regression were used to analyze the risk factors of postoperative AM.Results Among 48 patients who underwent MitraClip,14 of them(29.2%)developed afterload-mismatched.For those without AM,their overall LVEF was improved after the operation;for patients in both AM group and non-AM group,their overall left ventricular end-diastolic diameter(LVEDd),left ventricular end-diastolic diameter volume index(LVEDVi)was reduced compared with the preoperative ones.Univariate regression analysis showed that C-reactive protein levels(OR 1.98,95%CI 1.02-3.83),platelets(OR 2.22,95%CI1.08-4.53),systemic immune infl ammation index(OR 1.96,95%CI 1.03-3.71)were associated with an increased risk of AM in patients undergoing MitraClip(all P<0.05),while those with larger right atrial diameter(OR 0.35,95%CI 0.13-0.93)or moderate to severe tricuspid regurgitation(OR 0.19,95%CI 0.05-0.81)were less likely to develop into AM(both P<0.05),which is still satisfi ed after adjustment.Conclusions For patients who underwent MitraClip,C-reactive protein levels,platelets and systemic immune inflammation index(SII)are associated with an increased risk of afterload mismatched,while those with larger right atr

关 键 词：二尖瓣钳夹术 后负荷不匹配 相关因素 LOGISTIC回归 

分 类 号：R541[医药卫生—心血管疾病]