截根疗法联合乳果糖治疗气机郁滞型功能性便秘的临床观察  

Clinical observation of root cutting therapy combined with lactulose in the treatment of functional constipation with Qi stagnation type

作　　者：王森 张小平 游金勇[1] 丘海先[1] 蔡亮亮 闭红函 许靖[1] WANG Sen;ZHANG Xiaoping;YOU Jinyong;QIU Haixian;CAI Liangliang;BI Honghan;XU Jing(Department of Traditional Chinese Medicine,the Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;Department of Paediatrics,Traditional Chinese Medicine Hospital of Tiandong County,Baise 531500,Guangxi,China;Department of Colorectal Medicine,the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Nanning 530024,Guangxi,China)

机构地区：[1]右江民族医学院附属医院中医科,广西百色533000 [2]广西百色市田东县中医医院儿科,广西百色531500 [3]广西中医药大学第一附属医院肛肠科,广西南宁530024

出　　处：《右江医学》2024年第9期790-796,共7页Chinese Youjiang Medical Journal

基　　金：广西壮族自治区中医药管理局自筹经费科研课题(GXZYL20220311)。

摘　　要：目的探讨截根疗法联合乳果糖对气机郁滞型功能性便秘患者的疗效。方法选取2023年1月至2024年4月门诊收治的90例气机郁滞型功能性便秘患者作为研究对象,根据就诊顺序分为西药对照组(DZ组)、中医外治组(JG组)及联合治疗组(LH组),每组30例,观察治疗前后三组临床疗效、单项临床症状、中医证候疗效、生活质量、不良反应等指标。结果三组临床总有效率比较差异有统计学意义(P<0.01),LH组与JG组的总有效率比较差异无统计学意义(P>0.05),但均高于DZ组(P<0.05)。治疗前,两组患者的粪便性状、排便顺畅程度、排便频率、排便时间、排便不尽感等单项症状积分比较差异无统计学意义(P>0.05);治疗后,LH组与JG组、DZ组三组排便性状间差异无统计学意义(P>0.05);LH组与JG组排便顺畅程度差异无统计学意义(P>0.05),但两组均优于DZ组(P<0.05);LH组排便频率优于JG组(P<0.05),JG组排便频率优于DZ组(P<0.05);LH组与JG组排便时间差异无统计学意义(P>0.05),且两组均优于DZ组(P<0.05);LH组与JG组排便不尽感差异无统计学意义(P>0.05),且两组均优于DZ组(P<0.05)。三组中医证候总有效率比较差异有统计学意义(P<0.01),LH组与JG组的总有效率比较差异无统计学意义(P>0.05),但均高于DZ组(P<0.05)。治疗后三组生活质量评分组间、时间点及交互差异均有统计学意义(P<0.05),疗程结束时,LH组与JG组积分比较差异无统计学意义(P>0.05),但两组均低于DZ组(P<0.05),疗程结束后1个月时LH组与JG组积分差异无统计学意义(P>0.05),且两组均显著低于DZ组(P<0.05)。三组不良反应发生率比较差异无统计学意义(P>0.05)。结论截根疗法联合乳果糖治疗气机郁滞型FC能够显著提高临床疗效,改善单项临床症状及中医证候,提高患者的生活质量,且安全性良好。Objective To explore the therapeutic effect of root cutting therapy combined with lactulose on patients with functional constipation of Qi stagnation type.Methods 90 patients with functional constipation of Qi stagnation type admitted to outpatient clinics from January 2023 to April 2024 were selected as research subjects.They were divided into western medicine control group(DZ group),traditional Chinese medicine external treatment group(JG group),and combination treatment group(LH group)according to the order of treatment,with 30 cases in each group.And then,clinical efficacy,single clinical symptoms,the efficacy of traditional Chinese medicine(TCM)syndrome,the quality of life,adverse reactions and other indicators were observed before and after treatment in the three groups.Results There was statistically significant difference in total effective rate among the three clinical groups(P<0.01),while there was no statistically significant difference in the total effective rate between the LH group and the JG group(P>0.05),but they were all higher than that of the DZ group(P<0.05).Before treatment,there was no statistically significant difference in the scores of individual symptoms such as defecation characteristics,smoothness of defecation,frequency of defecation,defecation time,and incomplete defecation between the two groups of patients(P>0.05).After treatment,there was no statistically significant difference in defecation characteristics among the LH group,the JG group,and the DZ group(P>0.05).There was no statistically significant difference in the smoothness of defecation between the LH group and the JG group(P>0.05),but both groups were superior to the DZ group(P<0.05);the defecation frequency of the LH group was better than that of the JG group(P<0.05),and the defecation frequency of the JG group was better than that of the DZ group(P<0.05).There was no statistically significant difference in defecation time between the LH group and the JG group(P>0.05),and both groups were superior to the DZ group(P<0.05);

关 键 词：功能性便秘 气机郁滞型 截根疗法 中医证候 临床疗效 

分 类 号：R247[医药卫生—中医临床基础]