冠状动脉扩张症:非冠状动脉粥样硬化性心脏病的特殊类型  

Coronary Artery Ectasia:A Specialized Type of Non-Coronary Atherosclerotic Heart Disease

作　　者：曾祥烨 王蔚宗 周桐羽 杜晓诗 孟庆欣 李丙松 高梅[1,2,3] ZENG Xiangye;WANG Weizong;ZHOU Tongyu;DU Xiaoshi;MENG Qingxin;LI Bingsong;GAO Mei(Department of Cardiology,The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia,Jinan 250014,Shandong,China;The Second Clinical College of Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China;School of Clinical Medicine,Shandong Second Medical University,Weifang 261000,Shandong,China)

机构地区：[1]山东第一医科大学第一附属医院山东省千佛山医院心血管病学科山东省医药卫生心律失常重点实验室,山东济南250014 [2]山东中医药大学第二临床医学院,山东济南250014 [3]山东第二医科大学临床医学院,山东潍坊261000

出　　处：《心血管病学进展》2024年第10期902-906,共5页Advances in Cardiovascular Diseases

基　　金：山东省千佛山医院国家自然科学基金培育基金(QYPY2020NSFC1012);济南市临床医学科技创新计划(202225074)。

摘　　要：冠状动脉扩张症(CAE)是临床上少见的一类心血管疾病,定义为冠状动脉节段性或弥漫性扩张,扩张处直径≥1.5倍相邻的正常血管直径。CAE发病率为0.3%~5.0%,临床表现主要包括典型心绞痛、非典型心绞痛或心肌梗死。该病病因尚未明确。因多数CAE患者合并冠状动脉粥样硬化性心脏病(CAD),早期研究认为CAE是CAD的一种特殊类型。然而此类观点一直存在争议,随着研究的深入,发现CAE患者有着独特的细胞因子环境及血脂谱,因此CAE可能是单独的一类临床疾病。现从动脉粥样硬化、炎症、脂质代谢等方面总结CAE和CAD的差异,并对CAE临床表现、预后、诊断和治疗方面做一综述。Coronary artery ectasia(CAE)is a rare clinical cardiovascular disease defined as segmental or diffuse dilatation of coronary arteries≥1.5 times the diameter of adjacent normal vessels.The prevalence of CAE is between 0.3%and 5.0%,and the clinical manifestations mainly include typical angina,atypical angina,or myocardial infarction.The etiology of CAE has not yet been clarified.Due to most patients with CAE combined with coronary atherosclerotic heart disease(CAD),early studies considered CAE as a specific type of CAD.However,such views have been controversial.Further research found that patients with CAE have a unique cytokine milieu and lipid profile.Therefore,CAE may be a separate category of clinical disease.This article summarizes the differences between CAE and CAD in terms of atherosclerosis,inflammation,and lipid metabolism,and provides an overview of the clinical manifestations,prognosis,diagnosis,and treatment of CAE.

关 键 词：冠状动脉扩张症 冠状动脉粥样硬化性心脏病 炎症 脂质代谢 

分 类 号：R541.4[医药卫生—心血管疾病]