动脉粥样硬化的免疫机制与治疗的研究进展  

Advances in Immune Mechanisms and Treatment of Atherosclerosis

作　　者：苟于芬 王宏宇 GOU Yufen;WANG Hongyu(The Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China;Peking University Shougang Hospital Vascular Medicine Center,Beijing 100144,China;Beijing Shijingshan District Vascular Medicine Key Specialty,Beijing 100144,China;Vascular Health Research Center of Peking University Health Science Center(VHRC-PKUHSC),Beijing 100144,China;National Key Laboratory of Vascular Homeostasis and Remodeling(Peking University),Beijing 100191,China;Heart and Vascular Health Research Center of Peking University Clinical Research Institute(HVHRC-PUCRI),Beijing 100191,China;Heart and Vascular Health Research Center of Chengdu Medical College,Sichuan(HVHRC-CMC),Chengdu 611730,Sichuan,China;Intelligent Heart and Vascular Health Digital Management Research Center,National Institute of Health Data Science at Peking University,Beijing 100191,China)

机构地区：[1]新疆医科大学第二临床医学院,新疆乌鲁木齐830054 [2]北京大学首钢医院血管医学中心,北京100144 [3]北京市石景山区血管医学重点学科,北京100144 [4]北京大学医学部血管健康研究中心,北京100144 [5]血管稳态和重构全国重点实验室(北京大学),北京100191 [6]北京大学临床研究所心脏和血管健康研究中心,北京100191 [7]成都医学院心脏和血管健康研究中心,四川成都611730 [8]北京大学健康医疗大数据国家研究院智慧化心脏和血管健康数字管理研究中心,北京100191

出　　处：《心血管病学进展》2024年第10期912-917,共6页Advances in Cardiovascular Diseases

基　　金：北京大学首钢医院临床重点项目建设项目(2019-Yuan-LC-01);2020年首都卫生发展科研专项(自主创新)(首发2020-2-6042);北京市石景山区血管医学重点专科项目(2020-2023)。

摘　　要：动脉粥样硬化(AS)是心血管疾病的首要原因,脑梗死、心肌梗死等并发症致残率及致死率高,严重影响人们的生活质量。在AS进程中,炎症是该病发生发展的核心。炎症激活巨噬细胞、中性粒细胞、T淋巴细胞等免疫细胞,并释放γ干扰素、肿瘤坏死因子-α和白细胞介素等炎症因子。这些炎症因子加剧活性氧的生成,活性氧导致斑块内氧化应激和组织损伤,进而破坏血管内皮的完整性及促进泡沫细胞形成、平滑肌细胞增殖和脂质沉积,最终形成斑块。同时,炎症还影响斑块的稳定性,增加斑块破裂的风险。因此,免疫炎症和AS之间存在密切联系,免疫细胞的异常激活和炎症因子的释放使斑块形成进而导致心血管疾病的发生。现对AS的免疫机制及治疗方法做一综述。Atherosclerosis(AS)is the primary cause of cardiovascular diseases,and the mortality and disability rate of cerebral infarction,myocardial infarction and other complications are high,which seriously affect people’s quality of life.In the course of AS,inflammation is the core of the development of the disease.Inflammation activates immune cells such as macrophages,neutrophils,and T lymphocytes,and releases inflammatory factors such as interferon-γ,tumor necrosis factor-α,and interleukin.These inflammatory factors exacerbate the production of reactive oxygen species,which lead to oxidative stress and tissue damage in plaques,thereby destroying the integrity of vascular endothelia and promoting foam cell formation,smooth muscle cell proliferation and lipid deposition,and eventually plaque formation.At the same time,inflammation also affects plaque stability and increases the risk of plaque rupture.Therefore,there is a close relationship between immune inflammation and AS,and the abnormal activation of immune cells and the release of inflammatory factors lead to the formation of plaque,which leads to the occurrence of cardiovascular diseases.This article reviews the immune mechanism and treatment of AS.

关 键 词：动脉粥样硬化 免疫机制 免疫细胞 免疫治疗 

分 类 号：R543.5[医药卫生—心血管疾病]