Apelin与内皮功能障碍相关心血管疾病的研究进展及其应用展望  

Research Progress and Application Prospects of Apelin in Cardiovascular Diseases Associated with Endothelial Dysfunction

作　　者：王妤 舒俊华 干意 涂丹娜 WANG Yu;SHU Junhua;GAN Yi;TU Danna(Department of Pediatrics,Maternal and Child Health Hospital of Hubei Province,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430070,Hubei,China)

机构地区：[1]华中科技大学同济医学院附属湖北妇幼保健院儿内科,湖北武汉430070

出　　处：《心血管病学进展》2024年第10期923-927,934,共6页Advances in Cardiovascular Diseases

基　　金：湖北省科技创新项目(2021CFB558)。

摘　　要：内皮细胞既是各种外界刺激和体液介质的靶细胞,又具有非常活跃的代谢功能,能分泌多种活性物质调节血管舒张,参与炎症反应以及血液凝固等过程。作为内源性多肽激素,Apelin可通过影响NO的利用、调节氧化应激、影响血小板功能、促进内皮细胞增殖迁移及血管生成等多种途径影响内皮细胞功能,维护循环系统的健康,在心血管疾病的诊疗中具备一定的前景。鉴于Apelin对内皮功能障碍的多维影响,现以Apelin为核心对其在心血管疾病的作用、机制及应用前景进行综述。Endothelial cells not only serve as target cells for various external stimuli and body fluids,but also have highly active metabolic functions.They can secrete plenty of active substances to regulate vasodilation,participate in inflammation reactions,and blood coagulation processes.Apelin,an endogenous peptide hormone,impacts endothelial function via nitric oxide utilization,oxidative stress regulation,platelet function,endothelial cell proliferation andmigration,angiogenesis and so on.Apelin maintains the health of the circulatory system and holds promise in the diagnosis and treatment of cardiovascular diseases.Therefore,this article will review the association between Apelin and endothelial dysfunction,and its role,mechanism,and prospects in cardiovascular diseases.In view of the multidimensional influence of Apelin on endothelial dysfunction,this article reviews its role,mechanism and application prospect in cardiovascular diseases with Apelin as the core.

关 键 词：内皮细胞 APELIN 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]