抗甲状腺素自身抗体干扰导致游离甲状腺素假性升高  

Falsely elevated free thyroxine due to interference with anti-thyroxine autoantibodies

作　　者：金京 单忠艳[1] 滕晓春[1] Jin Jing;Shan Zhongyan;Teng Xiaochun(Department of Endocrinology and Metabolism,Institute of Endocrinology,National Health Commission Key Laboratory of Diagnosis and Treatment of Thyroid Diseases,the First Hospital of China Medical University,Shenyang 110001,China;Department of Endocrinology and Metabolism,Jilin Central General Hospital,Jilin 132000,China)

机构地区：[1]中国医科大学附属第一医院内分泌与代谢病科,内分泌研究所,卫健委(共建)甲状腺疾病诊治重点实验室,沈阳110001 [2]吉林市中心医院内分泌与代谢病科,吉林132000

出　　处：《中华内分泌代谢杂志》2024年第9期785-788,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(82270831,81970681)。

摘　　要：本文报道1例新型冠状病毒肺炎(COVID-19)感染后游离甲状腺素(FT_(4))升高的66岁男性患者的临床诊治经过。患者甲状腺功能检测结果显示,FT_(4)明显升高,而促甲状腺激素(TSH)未受抑制。在不同检测平台复测发现FT_(4)未出现一致性升高,这提示FT_(4)的检测可能受到了干扰。放射免疫沉淀试验证明患者体内存在抗甲状腺素自身抗体(T_(4)Ab),且为IgM亚型。复习相关文献,侧重阐述甲状腺激素自身抗体干扰的识别和鉴别诊断。This article reports the clinica diagnosis and treatment of a 66-year-old male patient with elevated free thyroxine(FT_(4))following coronavirus disease 2019(COVID-19)infection.The thyroid function tests showed a significant increase in FT_(4),while thyroid stimulating hormone(TSH)was not suppressed.Re-testing on different platforms revealed inconsistent FT_(4) elevations,indicating potential interference in FT_(4) measurement.Radioimmunoprecipitation assays confirmed the presence of anti-thyroxine autoantibodies(T_(4)Ab)in the patient′s body,specifically the IgM subtype.This article reviews relevant literature,focusing on the identification and differential diagnosis of thyroid hormone autoantibodies interference.

关 键 词：甲状腺激素自身抗体 免疫分析 检测干扰 

分 类 号：R581[医药卫生—内分泌]