PRP结合加味六味地黄汤促进膝骨关节炎康复的临床研究  

Clinical study on PRP combined with modified Liuwei Dihuang Tang to promote rehabilitation of knee osteoarthritis

作　　者：卢志兴 谢文伟 Lu Zhixing;Xie Wenwei(Dongguan First Hospital Affiliated to Guangdong Medical University,Dongguan,Guangdong 523710,China;Dongguan Songshan Lake Central Hospital Affiliated to Guangdong Medical University,Dongguan,Guangdong 523429,China)

机构地区：[1]广东医科大学附属东莞第一医院,广东东莞523710 [2]广东医科大学附属东莞松山湖中心医院,广东东莞523429

出　　处：《首都食品与医药》2024年第20期147-150,共4页Capital Food Medicine

摘　　要：目的探讨富血小板血浆(PRP)结合加味六味地黄汤在促进膝骨关节炎康复中的临床效果.方法将144例符合标准的膝骨关节炎患者按随机数字表法随机分配,其中观察组使用PRP局部关节腔注射结合口服加味六味地黄汤治疗,对照组1采用PRP局部关节腔注射,对照组2采用口服氨基葡萄糖胶囊治疗,对照组3口服加味六味地黄汤,四组患者均指导康复训练,各组均36例,疗程为90d.对比四组骨关节炎指数、膝关节功能、相关骨代谢指标、相关血清学因子.结果治疗干预后,观察组患者骨关节炎指数评分低于对照组1、对照组2及对照组3,膝关节功能评分高于对照组1、对照组2及对照组3(P<0.05);观察组患者骨保护素(OPG)、骨钙素(OCN)指标高于对照组1、对照组2及对照组3,观察组患者Ⅱ型胶原C端肽(CTX-Ⅱ)指标低于对照组1、对照组2及对照组3(P<0.05);观察组患者白细胞介素-1β(IL-1β)、白细胞介素-1(IL-1)指标低于对照组1、对照组2及对照组3,观察组患者沉默信息调节因子1(SIRT 1)指标高于对照组1、对照组2及对照组3(P<0.05).结论PRP结合加味六味地黄汤治疗膝骨关节炎的临床效果显著,可积极改善患者膝关节功能、骨代谢情况,减轻机体炎性反应,调节SIRT 1指标.Objective To explore the clinical study of platelet rich plasma(PRP)combined with modified Liuwei Dihuang Tang in pro-moting the rehabilitation of knee osteoarthritis.Methods 144 patients with knee osteoarthritis who met the criteria were randomly assigned using a random number table method.The observation group was treated with PRP local joint cavity injection combined with oral Jiawei Liuwei Dihuang Tang.Control group 1 was treated with PRP local joint cavity injection,control group 2 was treated with oral glucosamine capsules,control group 3 was treated with Jiawei Liuwei Dihuang Tang.All four groups of patients were guided by rehabilitation training,with 36 cases in each group and a course of 90 days.Compare four groups of osteoarthritis index,knee joint function,related bone metab-olism indicators,and related serological factors.Results After treatment intervention,the osteoarthritis index score of the observation group patients was lower than that of control group 1,control group 2,and control group 3,and the knee joint function score was higher than that of control group 1,control group 2,and control group 3(P<0.05);the levels of osteoprotegerin(OPG)and osteocalcin(OCN)in the observation group were higher than those in control group 1,control group 2,and control group 3.The levels of typeⅡcollagen C-ter-minal peptide(CTX-Ⅱ)in the observation group were lower than those in control group 1,control group 2,and control group 3(P<0.05);observation group patients with interleukin-1β(IL-1β),the interleukin-1(IL-1)index was lower than that of control group 1,control group 2,and control group 3.The SIRT 1 index of patients in the observation group was higher than that of control group 1,control group 2,and control group 3(P<0.05).Conclusion The clinical effect of PRP combined with modified Liuwei Dihuang Tang in treating knee osteoarthritis is significant,which can actively improve knee joint function and bone metabolism,alleviate inflammatory reactions,and regulate SIRT 1 index in patients.

关 键 词：富血小板血浆 加味六味地黄汤 膝骨关节炎 骨代谢 

分 类 号：R684.3[医药卫生—骨科学]