Ala-Gln双肽肠外营养支持在胃肠道肿瘤患者化疗期间的应用效果  

Effect of parenteral nutrition support with Ala-Gln dipeptide on patients with gastrointestinal tumors during chemotherapy

作　　者：王景景 魏鹏 Wang Jingjing;Wei Peng(Department of Pharmacy,No.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000,China;Department of Geneal Surgery,No.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000,China)

机构地区：[1]陕西省核工业二一五医院药学部,咸阳712000 [2]陕西省核工业二一五医院普通外科,咸阳712000

出　　处：《中国实用医刊》2024年第17期58-61,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨丙氨酰谷氨酰胺(Ala-Gln)双肽肠外营养支持在胃肠道肿瘤患者化疗期间的应用效果。方法队列研究。抽取2020年4月至2023年4月陕西省核工业二一五医院收治的140例胃肠道肿瘤患者作为研究对象,按随机数字表法分为对照组与研究组,每组70例。所有入选患者均行化疗,对照组仅接受常规的肠外营养支持治疗,研究组在对照组治疗基础上添加Ala-Gln双肽,比较两组化疗进展情况、营养状况[白蛋白(ALB)、前白蛋白(PA)、总蛋白(TP)、体质指数(BMI)]、氮平衡及并发症发生率。结果研究组化疗完成率(92.86%,65/70)高于对照组(77.14%,54/70),化疗完成周期长于对照组(P<0.05)。化疗前,两组TP、BMI、ALB和PA水平比较差异未见统计学意义(P>0.05);化疗后1周,两组上述指标比较差异有统计学意义(P<0.05)。化疗前,两组氮平衡比较差异未见统计学意义(P>0.05);化疗后1周,研究组氮平衡高于对照组(P<0.05)。研究组不良反应发生率(10.00%,7/70)低于对照组(30.00%,21/70),P<0.05。结论胃肠道肿瘤化疗患者实施Ala-Gln双肽肠外营养支持可显著改善患者营养状态及氮平衡,降低化疗的相关不良反应发生率,有利于治疗方案的顺利完成,提高患者生活质量。Objective To investigate the effects of parenteral nutrition support with alanyl-glutaminee(Ala-Gln)dipeptide on patients with gastrointestinal tumors during chemotherapy.Methods A total of 140 patients with gastrointestinal tumors admitted to No.215 Hospital of Shaanxi Nuclear Industry from April 2020 to April 2023 were selected as the research objects for a cohort study.And they were divided into a control group and a study group using a random number table method,with 70 cases in each group.All the enrolled patients received chemotherapy.The control group only received conventional parenteral nutrition support,while the study group was given Ala-Gln dipeptide additionally.The chemotherapy progress,nutritional status assessed by albumin(ALB),prealbumin(PA),total protein(TP)and body mass index(BMI),and incidence of complications were compared between the two groups.Results The completion rate of chemotherapy of the study group(92.86%,65/70)was higher than that of the control group(77.14%,54/70),and the completion course of chemotherapy of the study group was longer than that of the control group(P<0.05).There was no significant difference in the levels of TP,BMI,ALB and PA between the two groups before chemotherapy(P>0.05);there were significant differences in the above indexes between the two groups 1 week after chemotherapy(P<0.05).Before chemotherapy,there was no significant difference in nitrogen balance between the two groups(P>0.05).And the nitrogen balance of the study group was higher than that of the control group 1 week after chemotherapy(P<0.05).The incidence of adverse reactions in the study group(10.00%,7/70)was lower than that in the control group(30.00%,21/70),P<0.05.Conclusions Parenteral nutrition supporwt ith1Ala-Gln1dipeptide duringcchemotherapyy for gastrointestinal tumor can significantly improve the nutritional status and nitrogen balance of patients,reduce the incidence of adverse reactions related to chemotherapy,contribute to the successful completion of the treatment plan,and then impro

关 键 词：肿瘤 胃肠道 丙氨酰谷氨酰胺 双肽 肠外营养支持 化疗 

分 类 号：R459.3[医药卫生—治疗学] R735[医药卫生—临床医学]