溴夫定治疗9例特殊带状疱疹临床效果与安全性分析  

Clinical efficacy and safety analysis of brivudine in treatment of 9 cases of special herpes zoster

作　　者：牟卫彩 卢祥婷 MOU Wei-cai;LU Xiang-ting(Department of Dermatology,Huanghe Science and Technology College Affiliated Hospital,Zhengzhou 450000,China;Department of Dermatology,People's Hospital of Henan University,Henan Provincial People's Hospital,Zhengzhou 450003,China)

机构地区：[1]黄河科技学院附属医院皮肤科,郑州450000 [2]河南大学人民医院,河南省人民医院皮肤科,郑州450003

出　　处：《医药论坛杂志》2024年第18期1988-1992,1997,共6页Journal of Medical Forum

摘　　要：目的探讨分析9例特殊带状疱疹患者的发病原因、临床特点、诊断、治疗及预后,分析溴夫定治疗老年、肝肾功能不全、免疫功能低下(或缺陷)及危重症带状疱疹患者的临床效果与安全性,以提高临床对此病的诊疗经验,促进患者康复,改善预后,提高生活质量。方法选取2021年9月—2022年9月河南省人民医院皮肤科收治的9例特殊带状疱疹患者,予以溴夫定片每天125 mg口服治疗,疗程7~10 d。观察患者临床疗效、治疗前后的疼痛程度的数字等级评分法数字评价量表(numeric pain rating scale,NPRS)及不良反应发生情况。结果9例特殊带状疱疹患者给予溴夫定抗病毒药物治疗,治疗1~2 d后无新发水疱出现,水疱干涸时间2~5 d,4~8 d后疱疹结痂,疼痛减轻时间1~2 d,疼痛完全消失时间10~21 d,10~21 d均已基本治愈,没有患者产生带状疱疹后遗神经痛。结论溴夫定应用于老年、肝肾功能不全、免疫功能低下(或缺陷)和重症带状疱疹患者的治疗时,可以起到缓解症状、加速皮疹愈合、缩短病程、阻断病毒播散的重要作用,显著提升临床治疗效果,降低患者机体疼痛程度,且溴夫定不会增加不良反应,安全性较高,值得临床推广与应用。Objective To analyze the etiology,clinical characteristics,diagnosis,treatment and prognosis of 9 cases of special herpes zoster patients.Analyze the clinical efficacy and safety of brivudine in the treatment of elderly,liver and kidney dysfunction,immune dysfunction(or deficiency),and critically ill patients with herpes zoster,in order to improve clinical experience in the diagnosis and treatment of this disease,promote patient recovery,improve prognosis,and enhance quality of life.Methods Totally 9 cases of special herpes zoster patients admitted to the Dermatology Department of Henan Provincial People's Hospital between September 2021 and September 2022 were treated with brivudine orally at a dose of 125mg per day for a course of 7-10 days.Observe the clinical efficacy of patients,the numerical pain rating scale(NPRS)before and after treatment,and the occurrence of adverse reactions.Results All these 9 patients with special herpes zoster were treated with brivudine and no new blisters appeared 1-2 days after treatment.The blister dries up for 2-5 days,and after 4-8 days,the blister scabs.The pain relief time was 1-2 days,and the complete disappearance time of the pain was 10-21 days.From 10-21 days,all herpes zoster patients have basically recovered,and no patient has developed postherpetic neuralgia(PHN).Conclusion Brivudine can be used for the treatment of elderly patients,those with liver and kidney dysfunction,immune dysfunction(or defects),and severe herpes zoster.It can play an important role in relieving symptoms,accelerating rash healing,shortening the course of the disease,and blocking virus spread.It significantly improves clinical treatment effectiveness,reduces patient body pain,and does not increase adverse reactions.Brivudine is safe and worthy of clinical promotion and application.

关 键 词：溴夫定 肝肾功能不全 免疫功能低下 重症带状疱疹 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]