阻塞性睡眠呼吸暂停低通气综合征合并脑梗死的中医证候分型与睡眠监测指标的相关性研究  

Study on the correlation between OSAHS and cerebral infarction syndrome types of traditional Chinese medicine and sleep monitoring index

作　　者：顾玉华[1] 胡倩[1] 王乐红[1] 杨群[1] 李慧慧[1] 赵晨[1] 周吉雯 王晨[1] GU Yuhua;HU Qian;WANG Lehong(Department of Neurology,Jiangsu Provincial Hospital of Traditional Chinese Medicine,Nanjing Jiangsu 210029,China)

机构地区：[1]江苏省中医院神经内科,江苏南京210029 [2]江苏省中医院睡眠检测中心,江苏南京210029

出　　处：《四川中医》2024年第10期98-101,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并脑梗死的中医证候分型与睡眠监测指标的相关性。方法:回顾性选取2021年1月~2023年10月江苏省中医院收治的OSAHS合并脑梗死患者140例为研究对象。统计患者中医证型分布,比较不同中医证型患者睡眠监测指标差异。结果:140例OSAHS合并脑梗死患者中医证型构成比由高到低分别为痰淤阻络证35例、风痰阻络证32例、气虚血瘀证28例、阴虚风动证26例、痰热腑实证19例;OSAHS合并脑梗死患者美国国立卫生院神经功能缺损评分(NIHSS)为阴虚风动证>气虚血瘀证>痰热腑实证>风痰阻络证>痰淤阻络证(P<0.05);OSAHS合并脑梗死患者平均血氧饱和度(MSaO_(2))、夜间最低血氧饱和度(LSaO_(2))、SaO_(2)<90%时间占总睡眠时间比(TS90%)为风痰阻络证>痰热腑实证>阴虚风动证>痰淤阻络证>气虚血瘀证,呼吸暂停低通气指数(AHI)、自发微觉醒、呼吸暂停最长时间为气虚血瘀证>风痰阻络证>阴虚风动证>痰淤阻络证>痰热腑实证,睡眠潜伏期(SL)、快速动眼睡眠潜伏期(REM-SL)为痰热腑实证>阴虚风动证>气虚血瘀证>痰淤阻络证>风痰阻络证,总睡眠时间(TST)、快速动眼期(REM)占比、睡眠效率(SE)为风痰阻络证>痰淤阻络证>气虚血瘀证>阴虚风动证>痰热腑实证(P<0.05)。结论:OSAHS合并脑梗死的中医证候分型与睡眠监测指标具有良好的相关性,可以为患者睡眠障碍辨证施治提供参考。Objective:To investigate the correlation between TCM syndrome types and sleep monitoring indexes of obstructive sleep apnea hypopnea syndrome(OSAHS)complicated with cerebral infarction.Methods:140 patients with OSAHS complicated with cerebral infarction admitted from January 2021 to October 2023 in Jiangsu Provincial Hospital of Traditional Chinese Medicine were retrospectively selected as the study objects.The distribution of TCM syndrome types of patients was counted,and the differences of sleep monitoring indexes among different TCM syndrome types were compared.Results:In 140 cases of OSAHS complicated with cerebral infarction,the proportion of TCM syndromes from high to low were 35 cases of phlegm stasis blocking collaterals,32 cases of wind-phlegm blocking collaterals,28 cases of qi deficiency and blood stasis,26 cases of yin deficiency and wind movement,19 cases of phlegm-heat syndrome.The neurological impairment score(NIHSS)of OSAHS patients with cerebral infarction was syndrome of yin deficiency and wind movement>qi deficiency and blood stasis>phlegm-heat syndrome>wind-phlegm blocking collaterals>phlegm stasis blocking collaterals(P<0.05).The mean blood oxygen saturation(MSaO_(2)),the minimum blood oxygen saturation at night(LSaO_(2)),and the proportion of SaO_(2)<90%to total sleep time(TS90%)in patients with OSAHS complicated with cerebral infarction were wind-phlegm blocking collaterals>phlegm-heat syndrome>yin deficiency and wind movement>phlegm stasis blocking collaterals>qi deficiency and blood stasis.Apnea with low ventilation index(AHI),spontaneous micro-awakening and longest duration of apnea were qi deficiency and blood stasis>wind-phlegm blocking collaterals>yin deficiency and wind movement>phlegm stasis blocking collaterals>phlegm-heat syndrome.Sleep latency(SL)and rapid eye movement sleep latency(REM-SL)were phlegm-heat syndrome>yin deficiency and wind movement>qi deficiency and blood stasis>phlegm stasis blocking collaterals>wind-phlegm blocking collaterals.Total sleep time(TST),rapid eye mov

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 脑梗死 中医证候分型 睡眠监测指标 

分 类 号：R56[医药卫生—呼吸系统] R743.3[医药卫生—内科学]