温经活血汤对EMS患者痛经症状、血清AEMAb、CA125、VEGF水平的影响及其意义  

Effect of Wenjing Huoxue Decoction in the treatment of EMS on patients with dysmenorrhea,serum AEMAb,CA125,VEGF levels and its significance

作　　者：王晓玲 曹艳春 何翠琴[2] WANG Xiaoling;CAO Yanchun;HE Cuiqin(Department of Obstetrics and Gynecology,Liuhe District Hospital of Traditional Chinese Medicine,Nanjing Jiangsu 211500,China;Department of Obstetrics and Gynecology,Taizhou People's Hospital,Taizhou Jiangsu 225300,China)

机构地区：[1]南京市六合区中医院妇产科,江苏南京211500 [2]泰州市人民医院妇产科,江苏泰州225300

出　　处：《四川中医》2024年第10期178-181,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探讨温经活血汤治疗子宫内膜异位症(EMS)患者的效果及其作用机制。方法:选取我院妇科收治的128例EMS患者,采用单中心、前瞻性临床研究,其中中西医组64例患者采用西医药物+口服温经活血汤治疗,西医组64例采用单纯西医方案治疗,疗程均为3个月;对比治疗前后患者的痛经程度、中医证候积分、血清抗子宫内膜抗体(AEMAb)、糖类抗原125(CA125)、血管内皮细胞生长因子(VEGF)、白细胞介素-8(IL-8)、包块平均直径变化及临床疗效。结果:治疗前,两组患者的中医证候总分、VAS评分差异无统计学意义(P>0.05);治疗后,中西医组患者的中医证候积分、VAS评分低于西医组(P<0.05);治疗前,两组患者的盆腔包块直径差异无统计学意义(P>0.05);治疗3个月时,中西医组患者的盆腔包块直径低于西医组(P<0.05);治疗前,两组患者的CA125、IL-8、VEGF测定值差异无统计学意义(P>0.05);治疗后,中西医组患者的CA125、VEGF测定值低于西医组(P<0.05);治疗前,两组患者AEMAb阳性率差异无统计学意义(P>0.05);治疗后,中西医组患者AEMAb阳性率低于西医组(P<0.05);治疗后,中西医组的痊愈率29.03%、显效率41.94%、有效率25.81%、无效率3.23%,西医组的痊愈率18.33%、显效率35.00%、有效率40.00%、无效率6.67%,中西医组优于对西医组(P<0.05)。结论:温经活血汤联合西医方案治疗EMS对于缩小包块直径、减轻临床症状、改善子宫内膜容受性具有一定的作用,在一定程度可以提高临床效果。Objective:To explore the effect and mechanism of TCM Wenjing Huoxue Decoction on patients with endometriosis(EMS).Methods:A single-center,prospective clinical study was conducted on 128 EMS patients admitted to the department of gynecology in our hospital.Among them,64 patients in the traditional Chinese and Western medicine group were treated with western medicine and oral Wenjing Huoxue Decoction,and the Western medicine group was treated with pure Western medicine.For 3 months;compare the patient s dysmenorrhea before and after treatment,TCM syndrome score,serum anti-endometrial antibody(AEMAb),carbohydrate antigen 125(CA125),vascular endothelial cell growth factor(VEGF),and interleukin-8(IL-8),the change of the average diameter of the mass and the clinical efficacy.Results:Before treatment,there was no significant difference in the total scores of TCM syndromes and VAS scores between the two groups of patients(P>0.05);after treatment,the scores of TCM syndromes and VAS scores of the TCM group were lower than those of the Western medicine group(P<0.05).Before treatment,there was no significant difference in the diameter of the pelvic mass between the two groups of patients(P>0.05);at 3 months of treatment,the diameter of the pelvic mass of the Chinese and Western medicine group was lower than that of the Western medicine group(P<0.05);before treatment,there was no significant difference in the measured values of CA125,IL-8 and VEGF between the two groups of patients(P>0.05);after treatment,the measured values of CA125 and VEGF in the Chinese and Western medicine group were lower than those in the Western medicine group(P<0.05);There was no significant difference in the positive rate of AEMAb between the two groups of patients(P>0.05);after treatment,the positive rate of AEMAb in the Chinese and Western medicine group was lower than that in the Western medicine group(P<0.05);after treatment,the recovery rate of the Chinese and Western medicine group was 29.03%.The effective rate is 41.94%,the effective rate is

关 键 词：温经活血汤 子宫内膜异位症 痛经 抗子宫内膜抗体 糖类抗原125 血管内皮细胞生长因子 

分 类 号：R711.51[医药卫生—妇产科学]