车前子联合头孢曲松对产β-内酰胺酶淋病奈瑟菌的体外抑菌效果研究  

The Inhibitory Effects of Plantago Seed Combined with Ceftriaxone againstβ-Lactamase Neisseria Gonorrhoeae in Vitro

作　　者：覃德明 万小菊 曾俊萍 许爱霞[1,2] 马增力 QIN De-ming;WAN Xiao-ju;ZENG Jun-ping;XU Ai-xia;MA Zeng-li(Jiangxi Provincial Maternal and Child Health Hospital,Nanchang330006;Medical College Affiliated Maternal and Child Health Hospital,Nanchang,Jiangxi330006)

机构地区：[1]江西省妇幼保健院,南昌330006 [2]南昌医学院附属妇幼保健院,江西南昌330006

出　　处：《实用中西医结合临床》2024年第20期1-4,8,共5页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

基　　金：江西省中医药管理局科技计划项目(编号:2021B716)。

摘　　要：目的探讨车前子乙醇提取物联合头孢曲松对产β-内酰胺酶淋病奈瑟菌的体外抑菌效果。方法采用微量肉汤稀释法分别测试车前子乙醇提取物和头孢曲松的单药最低抑菌浓度及两药联合时的部分抑菌浓度指数。结果头孢曲松对产β-内酰胺酶淋病奈瑟菌的最低抑菌浓度为0.06μg/mL;车前子乙醇提取物对产β-内酰胺酶淋病奈瑟菌的最低抑菌浓度为128μg/mL;两药联合时的部分抑菌浓度指数为1,提示两药联合用药时为相加作用,抗菌活性稍有增加。结论车前子乙醇提取物对产β-内酰胺酶淋病奈瑟菌具有良好的抑菌活性;头孢曲松对产β-内酰胺酶淋病奈瑟菌的体外抑菌活性较高;头孢曲松可以联合车前子乙醇提取物对产β-内酰胺酶淋病奈瑟菌产生抑菌作用,但效果不显著。Objective To explore the inhibitory effects of ethanol extract of Plantago seed combined with ceftriaxone against productionβ-lactamase Neisseria gonorrhoeae in vitro.Methods The minimum inhibitory concentration of single drug and the partial inhibitory concentration index of the combination of ethanol extract of Plantago seed and ceftriaxone were tested by microbroth dilution method.Test the fractional inhibitory concentration index of the dual drug combination using the micro broth chessboard dilution method.Results The minimum inhibitory concentration of ceftriaxone against Neisseria gonorrhoeae with lactamase is 0.06μg/mL.The minimum inhibitory concentration of ethanol extract of Plantago seed on productionβ-lactamase Neisseria gonorrhoeae is 128μg/mL.The fractional inhibitory concentration index(FIC)of the combination of the two drugs is 1,indicating that the antibacterial activity was slightly increased when the two drugs were combined.Conclusions The ethanol extract of Plantago seed has good antibacterial activity against producingβ-lactamase Neisseria gonorrhoeae.The antibacterial activity of ceftriaxone for producingβ-lactamase Neisseria gonorrhoeae is relatively high in vitro.Ceftriaxone can be combined with the ethanol extract of Plantago seed to inhibitβ-lactamase-producing Neisseria gonorrhoeae,but the effect is not significant.

关 键 词：淋病奈瑟菌 Β-内酰胺酶 车前子乙醇提取物 头孢曲松 体外抑菌 

分 类 号：R759.2[医药卫生—皮肤病学与性病学]