胺碘酮联合福辛普利治疗冠心病阵发性房颤的临床效果分析  

Clinical Effect of Amiodarone Combined with Fosinopril in the Treatment of Paroxysmal Atrial Fibrillation

作　　者：魏丽萍 Wei Liping(Department of Internal Medicine,Beijing Tongrentang First Hospital of Integrated Traditional Chinese and Western Medicine,Beijing 100071,China)

机构地区：[1]北京同仁堂第一中西医结合医院内科,北京100071

出　　处：《中国社区医师》2024年第27期37-39,共3页Chinese Community Doctors

摘　　要：目的:分析胺碘酮联合福辛普利治疗冠心病阵发性房颤的临床效果。方法:选取2022年1月—2023年8月北京市朝阳区呼家楼第二社区卫生服务中心收治的冠心病阵发性房颤患者70例作为研究对象,采用随机数字表法分组,即对照组和观察组,各35例。对照组给予胺碘酮治疗,观察组在对照组基础上联合福辛普利治疗。对比两组治疗效果、阵发性房颤发作情况、心功能指标、炎性因子水平及药物不良反应。结果:观察组治疗总有效率高于对照组(P=0.019)。治疗后,两组阵发性房颤发作频率低于治疗前,且观察组低于对照组,两组心房颤动持续时间短于治疗前,且观察组短于对照组(P<0.05)。治疗后,两组左室舒张末期内径、左室收缩末期内径均短于治疗前,且观察组比对照组短,两组左室射血分数高于治疗前,且观察组比对照组高(P<0.05)。治疗后,两组超敏C反应蛋白水平、白细胞介素-6、肿瘤坏死因子-α水平均比治疗前低,且观察组比对照组低(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P=0.359)。结论:胺碘酮联合福辛普利治疗冠心病阵发性房颤的临床效果较好,可降低患者的阵发性房颤发作频率,缩短心房颤动时间,改善患者心功能,抑制炎性反应,且安全性较高。Objective:To analyze the clinical effect of amiodarone combined with fosinopril in the treatment of paroxysmal atrial fibrillation.Methods:A total of seventy patients with paroxysmal atrial fibrillation of coronary heart disease admitted to the Second Community Health Service Center of Hujialou,Chaoyang District,Beijing from January 2022 to August 2023 were selected as the study objects.Random number table method was used to divide them into control group and observation group,with thirty-five cases in each group.The control group was treated with amiodarone and the observation group was treated with fosinopril on the basis of the control group.The therapeutic effect,paroxysmal atrial fibrillation,cardiac function indexes,inflammatory factors and adverse drug reactions were compared between the two groups.Results:The total effective rate of observation group was higher than that of control group(P=0.019);after treatment,the frequency of paroxysmal AF in two groups was lower than before treatment,and the observation group was lower than the control group,and the duration of AF in two groups was shorter than before treatment,and the observation group was shorter than the control group(P<0.05);after treatment,left ventricular end-diastolic diameter and left ventricular end-systolic diameter in both groups were shorter than before treatment,and the observation group was shorter than the control group,the left ventricular ejection fraction in both groups was higher than before treatment,and the observation group was higher than the control group(P<0.05);after treatment,the levels of hypersensitive C-reactive protein,interleukin-6 and tumor necrosis factor-αin both groups were lower than before treatment,and the observation group was lower than the control group(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P=0.359).Conclusion:Amiodarone combined with fosinopril has good clinical effect in the treatment of paroxysmal atrial fibrillation,which can reduce the fr

关 键 词：冠心病 阵发性房颤 胺碘酮 福辛普利 

分 类 号：R541.75[医药卫生—心血管疾病]