厄贝沙坦片与硝苯地平缓释片治疗轻中度高血压的临床效果比较  

Comparison of Clinical Effect of Irbesartan Tablets and Nifedipine Sustained-Release Tablets in Treatment of Mild to Moderate Hypertension

作　　者：杨震 张光伟 Yang Zhen;Zhang Guangwei(Zhangwan Street Health Center in Caidian District,Wuhan 430100,Hubei Province,China;Yuxian Street Health Center in Caidian District,Wuhan 430100,Hubei Province,China)

机构地区：[1]武汉市蔡甸区张湾街道卫生院,湖北武汉430100 [2]武汉市蔡甸区玉贤街道卫生院,湖北武汉430100

出　　处：《中国社区医师》2024年第27期61-63,共3页Chinese Community Doctors

摘　　要：目的:分析比较厄贝沙坦片与硝苯地平缓释片治疗轻中度高血压的临床效果。方法:选取2020年3月—2022年3月于武汉市蔡甸区张湾街道卫生院就诊的96例轻中度高血压患者作为研究对象,以双色球法分为观察组和对照组,各48例。对照组采用厄贝沙坦片治疗,观察组采用硝苯地平缓释片治疗。比较两组血压水平、血压变异性、耐受性。结果:治疗前,两组收缩压(SBP)、舒张压(DBP)水平比较,差异无统计学意义(P>0.05);治疗后,两组SBP、DBP均低于治疗前(P<0.05),但两组血压水平差异不显著(P>0.05)。治疗前,两组24 h收缩压标准差(24 hSBPSD)、24 h舒张压标准差(24 hDBPSD)比较,差异无统计学意义(P>0.05);治疗后,对照组24 hSBPSD、24 hDBPSD水平与治疗前比较,差异无统计学意义(P>0.05);观察组24 hSBPSD、24 hDBPSD水平低于治疗前,且低于对照组(P<0.05)。治疗前后,两组尿素氮、肌酐水平比较,差异无统计学意义(P>0.05)。结论:厄贝沙坦片和硝苯地平缓释片均具有较好的降压效果,安全性较高,硝苯地平在改善收缩压变异性方面效果更好。Objective:To analyze the clinical effect of irbesartan tablets and nifedipine sustained-release tablets in treatment of mild to moderate hypertension.Methods:A total of 96 patients with mild to moderate hypertension who were admitted to Zhangwan Street Health Center in Caidian District of Wuhan City from March 2020 to March 2022 were selected as the study subjects.They were divided into two groups using the double-color ball method,with 48 cases in each group.The control group was treated with irbesartan tablets,and the observation group was treated with nifedipine sustained-release tablets.Blood pressure levels,blood pressure variability,and tolerability were compared between the two groups.Results:Before treatment,there was no significant difference in systolic blood pressure(SBP)and diastolic blood pressure(DBP)between the two groups(P>0.05).After treatment,the SBP and DBP in the two groups were lower than those before treatment(P<0.05),but there was no significant difference in blood pressure levels between the two groups(P>0.05).Before treatment,there was no significant difference in the 24-hour systolic blood pressure standard deviation(24 hSBPSD)and 24 h diastolic blood pressure standard deviation(24 hDBPSD)between the two groups(P>0.05).After treatment,there was no significant difference in the levels of 24 hSBPSD and 24 hDBPSD in the control group compared with those before treatment(P>0.05).The levels of 24 hSBPSD and 24 h DBPSD in the observation group were lower than those before treatment,and lower than those in the control group(P<0.05).Before and after treatment,there was no significant difference in the levels of urea nitrogen and creatinine between the two groups(P>0.05).Conclusion:Both irbesartan tablets and nifedipine extended-release tablets have good antihypertensive effect and high safety,and nifedipine has a better effect in improving systolic blood pressure variability.

关 键 词：高血压 厄贝沙坦 硝苯地平 

分 类 号：R544.1[医药卫生—心血管疾病]