N-末端脑钠肽前体、甘油三酯/高密度脂蛋白胆固醇在老年2型糖尿病合并高血压左室重构预测中的应用价值  

Application Value of N-terminal Brain Natriuretic Peptide Precursors,Triglycerides/High Density Lipoprotein Cholesterol in Predicting Left Ventricular Remodeling in Elderly Patients with Type 2 Diabetes Mellitus Complicated with Hypertension

作　　者：郑宇 刘思雨 Zheng Yu;Liu Siyu(Department of Clinical Laboratory,Beijing Chaoyang District Anzhen Community Health Service Center,Beijing 100011,China)

机构地区：[1]北京市朝阳区安贞社区卫生服务中心检验科,北京100011

出　　处：《中国社区医师》2024年第27期109-111,共3页Chinese Community Doctors

摘　　要：目的:探讨N-末端脑钠肽前体(NT-proBNP)、甘油三酯/高密度脂蛋白胆固醇(TG/HDL-C)在老年2型糖尿病(T2DM)合并高血压左室重构预测中的应用价值。方法:选取2021年2月—2024年2月北京市朝阳区安贞社区卫生服务中心收治的79例老年T2DM合并高血压患者作为观察组,另选取同期收治的79例T2DM患者作为对照组。所有受试者进行心脏超声检查,并检测NT-proBNP、TG、HDL-C水平及心室重构指标[左心房内径(LAD)、左室舒张末内径(LEEVD)及左室射血分数(LVEF)],计算TG/HDL-C。采用Pearson相关系数法分析NT-proBNP、TG/HDL-C与心室重构指标的相关性。结果:观察组NT-proBNP、TG/HDL-C、LAD、LVEDD水平高于对照组,LVEF水平低于对照组(P<0.001)。Pearson分析结果显示,NT-proBNP、TG/HDL-C与LAD、LVEDD呈正相关,与LVEF呈负相关(P<0.001)。结论:NT-proBNP、TG/HDL-C在老年T2DM合并高血压左室重构预测中的应用价值较高,可作为心室重构的辅助预测指标。Objective:To investigate the application value of N-terminal brain natriuretic peptide precursor(NT-proBNP)and triglyceride/high-density lipoprotein cholesterol(TG/HDL-C)in predicting left ventricular remodeling in elderly patients with type 2 diabetes mellitus(T2DM)complicated with hypertension.Methods:A total of seventy-nine elderly T2DM patients with hypertension admitted to Beijing Chaoyang District Anzhen Community Health Service Center from February 2021 to February 2024 were selected as the observation group,and another seventy-nine T2DM patients admitted during the same period were selected as the control group.Cardiac ultrasound was performed in all subjects,and the levels of NT-proBNP,TG,HDL-C and ventricular remodeling indexes[left atrial inner diameter(LAD),left ventricular end-diastolic inner diameter(LEEVD)and left ventricular ejection fraction(LVEF)]were detected.The TG/HDL-C was calculated.Pearson correlation coefficient method was used to analyze the correlation between NT-proBNP,TG/HDL-C and ventricular remodeling indexes.Results:The levels of NT-proBNP,TG/HDL-C,LAD and LVEDD in the observation group were higher than those in the control group,and the levels of LVEF were lower than those in the control group(P<0.001);the results of Pearson analysis showed that NT-proBNP and TG/HDL-C were positively correlated with LAD and LVEDD,but negatively correlated with LVEF(P<0.001).Conclusion:NT-proBNP and TG/HDL-C have high application value in predicting left ventricular remodeling in elderly patients with T2DM complicated with hypertension,and can be used as auxiliary predictors of ventricular remodeling.

关 键 词：2型糖尿病 高血压 N-末端脑钠肽前体 甘油三酯 高密度脂蛋白胆固醇 左室重构 

分 类 号：R587.2[医药卫生—内分泌]