非金属1,8-二氮杂双环[5.4.0]十一碳-7-烯介导下乙缩醛酸与异硫氰酸酯反应合成α-缩醛基酰胺  

Metal-Free 1,8-Diazabicyclo(5.4.0)-undec-7-ene Mediated Synthesis ofα-Acetal Amides through Reaction of Glyoxylic Acid Acetalde with Aryl Isothiocyanates

作　　者：丁柔 石思雨 马超 魏伟[1,2] 吕玉芬 Ding Rou;Shi Siyu;Ma Chao;Wei Wei;LüYufen(School of Chemistry and Chemical Engineering,Qufu Normal University,Qufu,Shandong 273165;CAS Key Laboratory of Tibetan Medicine Research,Northwest Institute of Plateau Biology,Chinese Academy of Sciences,Xining 810008)

机构地区：[1]曲阜师范大学化学与化工学院,山东曲阜273165 [2]中国科学院西北高原生物研究所、中国科学院藏药研究重点实验室,西宁810008

出　　处：《有机化学》2024年第7期2216-2222,共7页Chinese Journal of Organic Chemistry

基　　金：山东省自然科学基金(No.ZR2021MB065);青海省科技国际合作专项(No.2022-HZ-813)资助项目。

摘　　要：报道了一种非金属介导下异硫氰酸酯与乙缩醛酸进行缩合反应合成α-乙缩醛基酰胺的方法.该反应简单地采用1,8-二氮杂双环[5.4.0]十一碳-7-烯(DBU)作为碱,无需任何金属催化剂及偶联试剂,在室温下实现了一系列α-乙缩醛基酰胺的绿色构建.Metal-free condensation reaction of glyoxylic acid acetalde with aryl isothiocyanates leading toα-acetal amides has been reported.The present protocol,which simply utilizes 1,8-diazabicyclo(5.4.0)-undec-7-ene(DBU)as base,provides a green and efficient approach to construct a series ofα-acetal amides in the absence of metal catalysts and stoichiometric amounts of coupling reagents.

关 键 词：非金属 α-缩醛基酰胺 乙缩醛酸 芳基异硫氰酸酯 

分 类 号：O623.626[理学—有机化学]