邻二碘芳烃和氢化钠产生芳炔用于硫醇的邻碘芳基化反应  

o-Iodoarylation of Thiols Enabled by Aryne Generated from o-Diiodoarene and Sodium Hydride

作　　者：刘典范 王健智 王梦晴 陈晓蓓 胡延维[1] 张士磊[1] Liu Dianfan;Wang Jianzhi;Wang Mengqing;Chen Xiaobei;Hu Yanwei;Zhang Shilei(Jiangsu Key Laboratory of Neuropsychiatric Diseases,Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development,College of Pharmaceutical Sciences,Soochow University,Suzhou,Jiangsu 215123)

机构地区：[1]苏州大学药学院、江苏省重大神经精神疾病研究重点实验室、江苏省精准诊疗药物创制工程研究中心,江苏苏州215123

出　　处：《有机化学》2024年第7期2363-2370,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.22271206,22071053);江苏省高校重点学科建设(PAPD);苏州市脑病诊疗国际联合实验室资助项目。

摘　　要：该方法使用廉价易得的试剂邻二碘芳烃和氢化钠生成苯炔,然后与硫醇发生反应,简单高效地合成邻碘芳基硫醚.值得注意的是,在反应中没有观察到像过渡金属催化那样得到的二硫醚副产物.该方法操作简单,条件温和,底物范围广泛,很多情况下都给出较高收率的产物.A simple and efficient method is described for the synthesis of o-iodoaryl thioethers by the reaction of thiols and aryne.The aryne is generated from inexpensive and readily available reagents o-diiodoarene and sodium hydride.Remarkably,no disulfide substituted byproduct was observed in the reactions which is different from transition metal-catalyzed process.This method features simple operation,mild reaction conditions,broad substrate scope,and high reaction yields for many cas-es.

关 键 词：芳炔 硫醇 邻二碘芳烃 氢化钠 邻碘芳基硫醚 

分 类 号：O621.25[理学—有机化学]