四苯乙烯酰胺类化合物的合成及其高灵敏度、高选择性识别Cu^(2+)  

Synthesis of Tetraphenylethylene Based Amides for Detection of Copper(II)Ion with High Sensitivity and Selectivity

作　　者：苏小龙 李健鹏 刘孟鑫 邹莉 杨得锁 冯海涛 Su Xiaolong;Li Jianpeng;Liu Mengxin;Zou Li;Yang Desuo;Feng Haitao(Aggregation-Induced Emission Research Center,College of Chemistry and Chemical Engineering,Baoji University of Arts and Sciences,Baoji,Shaanxi 721000)

机构地区：[1]宝鸡文理学院化学化工学院聚集诱导发光研究中心,陕西宝鸡721000

出　　处：《有机化学》2024年第8期2581-2587,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.52173152,21805002);陕西省科技创新团队(No.2022TD-36);陕西省自然科学基金(No.2024JC-YBMS-123);陕西省教育厅服务地方(No.23JC001)资助项目。

摘　　要：设计合成了一种四苯乙烯基酰胺类荧光探针TPE-Py,并对其结构进行了表征.通过荧光发射光谱和He La细胞成像实验研究了其金属离子识别性能.结果表明:探针TPE-Py对Cu^(2+)具有较好的选择性和灵敏性,在H2O/THF(V∶V=9∶1)溶液中对Cu^(2+)显示出荧光淬灭效应,且不受其他金属离子干扰.细胞成像实验表明,探针TPE-Py可以检测细胞脂滴中的Cu^(2+).The fluorescent probe TPE-Py was designed and synthesized,and its structure was confirmed by NMR and HRMS.The recognition properties of probe TPE-Py for metal ions have been studied through fluorescence spectrophotometry and cell imaging experiments in HeLa cells.The results showed that TPE-Py had good selectivity and sensitivity for Cu^(2+).Among various metal ions,TPE-Py only showed exclusive fluorescence turn-off sensing on Cu^(2+)in H2O/THF(V∶V=9∶1).The results of cell imaging experiments showed that the probe TPE-Py could detect Cu^(2+)in lipid droplets of cells.

关 键 词：聚集诱导发光 荧光探针 离子识别 细胞成像 

分 类 号：O657.3[理学—分析化学]