基于MR的脑功能成像评估皮层下血管性认知障碍的研究进展  

Research progress on MR-based functional brain imaging in the evaluation of subcortical vascular cognitive impairment

作　　者：方向明 毛海霞 FANG Xiangming;MAO Haixia(Department of Medical Imaging,the Affiliated Wuxi People's Hospital of Nanjing Medical University,Wuxi Medical Center,Nanjing Medical University,Wuxi 214023,China)

机构地区：[1]南京医学科大学无锡医学中心,南京医科大学附属无锡人民医院医学影像科,无锡214023

出　　处：《中国研究型医院》2024年第5期16-22,共7页Chinese Research Hospitals

摘　　要：皮层下血管性认知障碍是一种与脑小血管病相关的认知功能障碍,是老年痴呆的主要病因,其具体发病机制尚不明确。神经功能MR通过评估神经系统的结构和功能的改变,进而深入挖掘脑小血管病引发的认知障碍的影像机制。研究认为,灰质体积缩小、白质完整性破坏、结构及功能连接的改变均可对脑小血管病患者的认知功能产生影响,是皮层下血管性认知障碍发病机制的重要影像依据。同时,神经影像检查在临床实践中也对皮层下血管性认知障碍的早期诊断、预后评估和治疗方案制定具有一定指导意义。Subcortical vascular cognitive impairment is a type cognitive dysfunction associated with cerebral small vessel disease and is a leading cause of Alzheimer’s disease.Its exact pathogenesis remains unclear.Neurofunctional MR imaging assesses changes in the structure and function of the nervous system,providing insights into the imaging mechanisms of cognitive impairment induced by cerebral small vessel disease.Research suggests that reductions in gray matter volume,disruption of white matter integrity,and alterations in structural and functional connectivity can all impact cognitive function in patients with cerebral small vessel disease,serving as important imaging evidence for the pathogenesis of subcortical vascular cognitive impairment.Additionally,neuroimaging examinations also have significant guiding value in the early diagnosis,prognosis assessment,and treatment planning of subcortical vascular cognitive impairment in clinical practice.

关 键 词：血管性认知障碍 磁共振成像 神经影像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.13[医药卫生—诊断学]