肿瘤免疫检查点抑制剂相关皮肤毒性管理的证据总结  

Evidence-based summary of the management for immune checkpoint inhibitor-rela-ted cutaneous toxicity

作　　者：杨智慧[1] 罗园园 卢睿琦 刘欣琪 柳涵钰 张丰翼 黄琛 张立力[1] Yang Zhihui;Luo Yuanyuan;Lu Ruiqi;Liu Xinqi;Liu Hanyu;Zhang Fengyi;Huang Chen;Zhang Lili(School of Nursing,Centre for Evidence-Based Nursing and Midwifery,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学护理学院,南方医科大学护理与助产循证中心,广东广州510515

出　　处：《护理学杂志》2024年第20期46-50,共5页Journal of Nursing Science

基　　金：国家自然科学基金青年项目(72204106);广东省医学科研基金项目(A202282)。

摘　　要：目的评价并总结免疫检查点抑制剂相关皮肤毒性管理的相关证据,为医护人员对肿瘤免疫检查点抑制剂相关皮肤毒性患者进行管理提供依据。方法系统检索国内外相关网站和数据库,查询关于肿瘤免疫检查点抑制剂相关皮肤毒性管理方面的指南、专家共识、证据总结、系统评价等证据。检索时间为建库至2024年4月30日,由2名具有循证护理知识的研究人员独立对文献进行质量评价和证据级别评定。结果共纳入19篇文献,包括指南7篇、专家共识10篇、系统评价1篇、临床决策1篇,从预防、评估、检查、治疗与护理、监测5个方面形成19条最佳证据。结论有效管理免疫检查点抑制剂相关皮肤毒性可改善皮肤症状,提高患者的生活质量。医护人员需考虑患者的意见,结合临床情境,为肿瘤免疫检查点抑制剂相关皮肤毒性患者提供个性化的指导。Objective To evaluate and summarize the evidence regarding the management of immune checkpoint inhibitor-related cutaneous toxicity,and to provide a basis for healthcare professionals to manage cancer patients developing immune checkpoint inhibitor-related cutaneous toxicity.Methods A systematic search was conducted in relevant domestic and international websites and databases.Guidelines,expert consensus reports,evidence summary reports,systematic reviews,and other evidence on the management of immune checkpoint inhibitor-related cutaneous toxicity in cancer patients were included.The search timeframe was from database inception to April 30,2024.Two researchers with expertise in evidence-based nursing independently assessed the quality and level of evidence of the literature.Results A total of 19 articles were included,comprising 7 guidelines,10 expert consensus statement reports,1 systematic review,and 1 clinical decision-making report.Nineteen pieces of best-evidence were formulated from five aspects:prevention,assessment,examination,treatment and care,and monitoring.Conclusion Effective management of immune checkpoint inhibitor-related cutaneous toxicity can alleviate cutaneous symptoms and improve patients′quality of life.Healthcare professionals should consider patients′preferences and tailor personalized guidance based on clinical circumstances for patients with immune checkpoint inhibitor-related cutaneous toxicity in cancer treatment.

关 键 词：肿瘤 免疫治疗 免疫检查点抑制剂 皮肤毒性 药物不良反应 循证护理 皮肤护理 

分 类 号：R473.73[医药卫生—护理学]