肠道微生物调控脂肪沉积及其代谢相关疾病的研究进展  

Research Progress of Gut Microbiota Regulating Fat Deposition and Metabolic Related Diseases

作　　者：徐兰梦 黄榆智 韩玉竹[1] 李常营 章杰[1] XU Lanmeng;HUANG Yuzhi;HAN Yuzhu;LI Changying;ZHANG Jie(College of Animal Science and Technology,Southwest University,Chongqing 402460,China)

机构地区：[1]西南大学动物科学技术学院,重庆402460

出　　处：《畜牧兽医学报》2024年第10期4263-4277,共15页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：重庆市自然科学基金(cstc2019jcyjmsxm2342)。

摘　　要：脂肪组织是机体的重要组成部分,不仅具有储存能量、保护组织和调节体温等作用,还能通过分泌细胞因子参与代谢调节,在肥胖及相关并发症的发病过程中发挥着重要作用。大量研究已证实,肠道微生物与宿主脂肪代谢及其相关疾病之间具有紧密联系。本文综述了肠道微生物影响脂肪沉积的主要因素,包括脂肪细胞、脂肪酸组成和脂肪相关血液指标。探讨肠道微生物如何通过一系列途径参与调节脂肪吸收、生成和分解过程,同时详细阐述了肠道微生物与脂肪代谢紊乱引起的疾病之间的关联。本文旨在完善和加深对肠道微生物调控脂肪沉积及其相关代谢疾病的了解,为下一步的研究和临床实践提供理论基础和借鉴。Adipose tissue is an important component of the body,which not only stores energy,protects tissues,and regulates body temperature,but also participates in metabolic regulation by secreting cytokines,playing an important role in the pathogenesis of obesity and related complications.Numerous studies have confirmed that,there exists a close relationship between gut microbiota and host fat metabolism and related diseases.This article reviews the main factors that gut microbiota affects fat deposition,including adipocytes,fatty acid composition,and fat related blood indicators.Exploring how gut microbiota participates in regulating fat absorption,generation,and decomposition processes through a series of pathways,and elaborating in detail the association between gut microbiota and diseases caused by lipid metabolism disorders.This article aims to improve and deepen the understanding of the regulation of fat deposition and related metabolic diseases by gut microbiota,providing a theoretical basis and reference for further research and clinical practice.

关 键 词：肠道微生物 脂肪 肥胖 糖尿病 MAFLD 

分 类 号：Q493.5[生物学—生理学]