纳米递送技术用于幽门螺杆菌疫苗研发的进展  

Research progress of nano-delivery technology for the development of vaccines against Helicobacter pylori

作　　者：宋紫娟 张远冬 SONG Zijuan;ZHANG Yuandong(School of Pharmacy,Zunyi Medical University,Zunyi 563000,China;First Clinical College of Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学药学院,563000 [2]遵义医科大学第一临床学院,563000

出　　处：《免疫学杂志》2024年第4期393-398,共6页Immunological Journal

基　　金：国家自然科学基金(82160678,82003686);贵州省卫生健康委科研基金(gzwkj2020-1-213);大学生创新训练项目(ZYDC202302032)。

摘　　要：幽门螺杆菌感染与一系列胃肠道疾病的发生息息相关,而目前用于抗幽门螺杆菌治疗的抗生素耐药性极大增加了感染复发率,导致其根治困难。疫苗是防治感染性疾病最有效的策略之一,然而,至今仍未有幽门螺杆菌疫苗上市。运用纳米技术提高疫苗稳定性和有效性已在实验室研究中初见成效,因此,本文对幽门螺杆菌疫苗的研发现状进行了总结,并归纳和讨论了幽门螺杆菌疫苗纳米递送系统的研究进展,包括黏液惰性纳米粒、耐酸性纳米粒、纳米囊泡等,以期为后续开发有效、安全的幽门螺杆菌疫苗提供参考。Helicobacter pylori(H.pylori)infection is closely related to the occurrence of a series of gastrointestinal diseases.Antibiotic resistance in the current H.pylori treatment has greatly increased the recurrence rate of the infection,making its eradication difficult.Vaccine is one of the most effective strategies to prevent and control bacterial infectious diseases,however,there is still no anti-H.pylori vaccine on the market.The use of nanotechnology to improve vaccine stability and efficacy has shown promising results in laboratory studies.This paper summarizes the current status of anti-H.pylori vaccine development,and reviews and discusses the research progress of H.pylori vaccine based on nano-delivery systems,including mucus-inert nanoparticles,acid-resistant nanoparticles,and outer-membrane vesicles etc.,with the aim of providing a reference for the subsequent development of an effective and safe H.pylori vaccine.

关 键 词：幽门螺杆菌 候选抗原 疫苗 纳米技术 

分 类 号：R392.9[医药卫生—免疫学] R945[医药卫生—基础医学]