微反应器内颜料红57连续化合成工艺  

Continuous-flow synthesis of Pigment Red 57 in a microreactor system

作　　者：王法军 陈安 徐建鸿 WANG Fajun;CHEN An;XU Jianhong(Microfluidic Green Manufacturing R&D Center,Research Institute of Tsinghua University in Shenzhen,Shenzhen 518071,Guangdong,China;Shenzhen Smart Micro Chemical Engineering Technology Co.,Ltd.,Shenzhen 518055,Guangdong,China;Department of Chemical Engineering,Tsinghua University,Beijing 100084,China)

机构地区：[1]深圳清华大学研究院微流控绿色制造研发中心,广东深圳518071 [2]深圳智微通科技有限公司,广东深圳518055 [3]清华大学化学工程系,北京100084

出　　处：《化工学报》2024年第10期3600-3609,共10页CIESC Journal

基　　金：国家自然科学基金青年科学基金项目(22208185)。

摘　　要：偶氮色淀颜料属于重要的有机颜料品种之一,广泛应用于各类工业领域。利用微反应器技术实现颜料红57的连续化合成,对于偶氮色淀颜料生产技术的革新有重要意义。首先,搭建微反应器系统,并在系统内对重氮化反应、偶合反应、色淀化反应过程进行反应条件优化。在最优的反应条件下,重氮盐的收率大于99%,颜料红收率大于99%,颜料红色淀后的固体回收率接近100%。然后,采用不同碱金属盐或者碱土金属溶液进行色淀化反应,实现对颜料色光的调控。其中,Sr^(2+)、Ba^(2+)色淀后色光偏亮,同时偏红偏黄;Zn^(2+)、Mg^(2+)、Mn^(2+)色淀后色光偏暗,同时偏绿偏蓝。Azo lake pigments are one of the important organic pigment varieties and are widely used in various industrial fields.The continuous-flow synthesis of Pigment Red 57 using the microreactor technology is of great significance for the innovation of azo lake pigments production technology.First,a microreactor system was built,and the reaction conditions of diazotization,coupling and laking process were optimized in the system.Under the optimal reaction conditions,the yield of diazonium salt was greater than 99%,the yield of pigment red was greater than 99%,and the solid recovery after laking was close to 100%.Finally,different alkali metal salts or alkaline earth metal solutions were used for laking process to achieve the regulation of chromatic light.Among them,the chromatic light after Sr^(2+)and Ba^(2+)laking was brighter,and the red and yellow hues were intense.The chromatic light after Zn^(2+),Mg^(2+),Mn^(2+)laking was dark,and the green and blue hues were intense.

关 键 词：微反应器 微尺度 重氮化反应 偶合反应 色淀化反应 偶氮色淀颜料 

分 类 号：TQ052.5[化学工程]