男性弱精子症发病机制的研究进展  

Pathogenesis of asthenozoospermia in males:Progress in research

作　　者：钱林 李文鑫 王瀚枢 荆涛[1] QIAN Lin;LI Wen-xin;WANG Han-shu;JING Tao(Department of Andrology,The Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China)

机构地区：[1]青岛大学附属医院男性科,山东青岛266000

出　　处：《中华男科学杂志》2024年第10期936-941,共6页National Journal of Andrology

基　　金：山东省自然科学基金(ZR2023QH491)。

摘　　要：弱精子症是男性不育症的主要病因之一,它的发病机制复杂多样,包括精子运动结构的异常、信号传导通路的异常、精子运动相关的能量代谢异常等多种因素。目前,发现存在于精浆中的细胞外囊泡(EV)对生精过程产生积极影响。而EV的作用过程是通过自身表面类似于脂质双分子层的结构与靶细胞直接融合的方式,将自身包裹的DAN,RNA,蛋白质等分子释放入靶细胞,从而调节其功能。本文将综述弱精子症发病机制的相关研究及进展,从而为弱精子症发病机制的科学研究提供理论依据。Asthenozoospermia is one of the major causes of male infertility,with complex pathogenesis,which involves abnormalities in sperm morphology,signaling pathways,sperm motility-related energy metabolism,and other factors.Currently,extracellular vesicles(EV)in the seminal plasma have been found with a positive effect on the spermatogenic process by releasing such self-encapsulated molecules as DAN,RNA and proteins into target cells through direct fusion with the structure similar to the lipid bilayer on the surface,and thereby regulating their function.This article reviews the research progress in the pathogenesis of asthenozoospermia,aiming to provide some theoretical evidence for its further studies.

关 键 词：弱精子症 精子结构 信号通路 能量代谢 

分 类 号：R698.2[医药卫生—泌尿科学]