口腔种植修复后龈沟液中炎症因子与种植体稳定的关联性分析  

Correlation between inflammatory factors in gingival crevicular fluid and implant stability after oral implant restoration

作　　者：秦坤 刘文静 李梦琦 汪俊兰 QIN Kun;LIU Wen-jing;LI Meng-qi;WANG Jun-lan(Department of Stomatology,Second People's Hospital of Hefei&Hefei Hospital Affiliated to Anhui Medical University.Hefei 230011,Anhui Province,China)

机构地区：[1]合肥市第二人民医院(安徽医科大学附属合肥医院)口腔科,安徽合肥230011

出　　处：《上海口腔医学》2024年第5期538-542,共5页Shanghai Journal of Stomatology

摘　　要：目的:探讨口腔种植修复后龈沟液中炎症因子水平及与种植体稳定性及预后的相关性。方法:选择2022年8月—2023年8月收治的78例口腔种植修复患者为试验组,根据种植后1个月复诊时X线片检查结果分为预后不良亚组(n=33)和预后良好亚组(n=45),选取同期60名健康体检者为对照组。收集所有研究对象的龈沟液,采用化学发光免疫法测定超敏C反应蛋白(high-sensitivity C-reactive proteinhs,CRP),酶联免疫吸附法测定淀粉样蛋白A(serum amyloid A,SAA)和降钙素原(procalcitonin,PCT)水平,术后记录种植体稳定系数(implant stability quotient,ISQ)。采用Pearson法评估龈沟液中炎症因子与ISQ的相关性,采用多因素logistic回归分析法分析龈沟液中炎症因子与种植体预后的关系。采用SPSS 22.0软件包对数据进行统计学分析。结果:试验组龈沟液hsCRP、SAA和PCT水平显著高于对照组(P<0.05),预后不良亚组龈沟液hsCRP、SAA和PCT水平显著高于预后良好亚组(P<0.05);试验组初期和二期ISQ值分别为(74.08±6.12)和(76.78±5.11)。Pearson相关性分析结果显示,口腔种植修复患者的龈沟液hsCRP、SAA、PCT与初期、二期ISQ呈显著负相关(P<0.05)。多因素logistic回归分析结果显示,龈沟液hsCRP、SAA和PCT是影响种植体预后的重要因素(P<0.05)。结论:口腔种植修复后龈沟液中hsCRP、SAA和PCT水平显著升高,与种植体稳定性及预后相关。PURPOSE:To study the correlation between the levels of inflammatory factors in gingival crevicular fluid and implant stability and prognosis after oral implant restoration.METHODS:A total of 78 patients who underwent oral implant restoration surgery from August 2022 to August 2023 were selected as the experimental group.According to the results of X-ray examination 1 month after implantation,the patients were divided into poor prognosis subgroup(n=33)and good prognosis subgroup(n=45),another 60 healthy subjects who underwent physical examination during the same period were selected as the control group.The gingival crevicular fluid of all research subjects was collected,and chemiluminescent immunoassay was used to determine high-sensitivity C-reactive protein(hsCRP),and enzyme-linked immunosorbent assay was used to determine amyloid A(SAA)and procalcitonin(PCT),implant stability quotient(ISQ)was recorded after surgery.Pearson's correlation analysis was used to evaluate the correlation between inflammatory factors in gingival crevicular fluid and ISQ,and multifactor logistic regression analysis was used to analyze the relationship between inflammatory factors in gingival crevicular fluid and implant prognosis.Statistical analysis was performed with SPSS 22.0 software package.RESULTS:The levels of hsCRP,SAA and PCT in the gingival crevicular fluid of the experimental group were significantly higher than the control group(P<0.05),the levels of hsCRP,SAA and PCT in the gingival crevicular fluid of the poor prognosis subgroup were significantly higher than the good prognosis subgroup(P<0.05).The initial and second-stage ISQ values of the patients in the experimental group were(74.08±6.12)and(76.78±5.11)respectively.Pearson's correlation analysis results showed that the gingival crevicular fluid hsCRP,SAA and PCT were significantly negatively correlated with initial and second-stage ISQ(P<0.05);multi-factor logistic regression analysis results showed that hsCRP,SAA and PCT in gingival crevicular fluid were important

关 键 词：口腔种植修复 龈沟液 炎症因子 种植体稳定性 预后 相关性 

分 类 号：R783.4[医药卫生—口腔医学]