EORTC QLQ-C30和FACT-Lym量表在中国淋巴瘤患者生活质量中的评价比较  

Consistency analysis of EORTC QLQ-C30 and FACT-Lym scale in the quality of life evaluation of patients with lymphoma in China

作　　者：林惜君 林洋 黄志聪 林梓乐 谢漫芬 LIN Xijun;LIN Yang;HUANG Zhicong;LIN Zile;XIE Manfen(State Key Laboratory of Oncology in South China&Guangdong Provincial Clinical Research Center for Cancer&Sun Yat-sen University Cancer Center,Guangzhou 510060,Guangdong,China)

机构地区：[1]华南恶性肿瘤防治全国重点实验室广东省恶性肿瘤临床医学研究中心中山大学肿瘤防治中心,广东广州510060

出　　处：《护士进修杂志》2024年第20期2160-2165,共6页Journal of Nurses Training

基　　金：广东省医学科学技术研究基金项目(编号:A2022103)。

摘　　要：目的评估欧洲癌症研究与治疗组织生活质量核心量表(European organization for research and treatment of cancer quality of life questionnaire core 30,EORTC QLQ-C30)和淋巴瘤患者生命质量测定量表(functional assessment of cancer therapy-lymphoma,FACT-Lym)在国内淋巴瘤患者中的适用性,并对2个量表进行一致性分析。方法选取2021年12月-2022年6月广东省某三级甲等医院305例经病理确诊后处于治疗阶段的淋巴瘤患者作为研究对象,采用上述2个量表调查受试对象健康相关生活质量(health-related quality of life,HRQoL),评估2个量表的集中趋势、内部一致性信度、聚合效度,通过Spearman相关检验2个量表的关联性。结果EORTC QLQ-C30集中趋势较差,FACT-Lym集中趋势良好。除EORTC QLQ-C30量表中认知功能领域,2个量表其余领域的Cronbach′sα系数>0.70即信度良好,平均方差提取值>0.36且组合信度>0.70即聚合效度良好。2个量表整体间存在显著的相关性(r>0.50),但对应领域间关联性一般,其中社会领域及功能领域对应相关性较弱(r<0.50)。结论EORTC QLQ-C30和FACT-Lym量表均是评估国内淋巴瘤患者HRQoL的有效工具,2者评估角度不同,不可互相替代。EORTC QLQ-C30量表集中趋势有待进一步优化,对于患者认知功能领域的评估不宜采纳该量表结果。Objective To evaluate the applicability of the European organization for research and treatment of cancer quality of life questionnaire core 30(EORTC QLQ-C30)and the functional assessment of cancer therapy-lymphoma(FACT-Lym)in lymphoma patients in China,and to analyze the consistency of 2 scales.Methods A total of 305 lymphoma patients in the treatment stage after pathological diagnosis in a tertiary grade a hospital in Guangdong province from December 2021 to June 2022 were selected as the research objects,and their health-related quality of life(HRQoL)was investigated with the above 2 scales.The concentration trend,internal consistency reliability,and aggregate validity of 2 scales were evaluated,and the correlation between 2 scales was tested by Spearman correlation.Results The central trend of EORTC QLQ-C30 was poor,and the central trend of FACT-Lym was good.In addition to the cognitive function domain in the EORTC QLQ-C30 scale,Cronbach'sα>0.70 in the other domains of 2 scales meansed good reliability,and the average variance extracted value>0.36 and the composite reliability>0.70 meansed good aggregate validity.There was a significant correlation between 2 scales as a whole(r>0.50),but the correlation between the corresponding domains was general,and the correlation between the social domain and the functional domain was weak(r<0.50).Conclusion EORTC QLQ-C30 and FACT-Lym scales are both effective tools to evaluate HRQoL in lymphoma patients in China,and they have different evaluation angles and cannot be replaced each other.The centralized trend of EORTC QLQ-C30 scale needs to be further optimized,and the results of this scale should not be adopted for the evaluation of patients'cognitive function.

关 键 词：淋巴瘤 健康相关生活质量 量表 量表评价 护理 

分 类 号：R473.55[医药卫生—护理学] R473.73[医药卫生—临床医学]