非洲猪瘟疫苗安全性评价部分关键指标研究现状与思考  

Review on Some Key Indicators for Safety Evaluation on African Swine Fever Vaccines and Some Reflections

作　　者：徐天刚[1,2,3] 郑辉 于小静[1] 左媛媛[1,3] 巩明霞[1] 王筱真 李金明[1] 魏荣 戈胜强[1,2,3] 王志亮[1] Xu Tiangang;Zheng Hui;Yu Xiaojing;Zuo Yuanyuan;Gong Mingxia;Wang Xiaozhen;Li Jinming;Wei Rong;Ge Shengqiang;Wang Zhiliang(China Animal Health and Epidemiology Center,Qingdao 266032,Shandong,China;Qingdao KeyLaboratory of Modern Bioengineering and Animal Disease Research,Qingdao 266032,Shandong,China;KeyLaboratory of Animal Biosafety Risk Warning Prevention and Control(South China),Ministry of Agriculture andRural Affairs,Qingdao 266032,Shandong,China)

机构地区：[1]中国动物卫生与流行病学中心,山东青岛266032 [2]青岛市现代生物工程及动物疫病研究重点实验室,山东青岛266032 [3]农业农村部动物生物安全风险预警及防控重点实验室(南方),山东青岛266032

出　　处：《中国动物检疫》2024年第10期47-52,共6页China Animal Health Inspection

基　　金：国家重点研发计划项目(2022YFD1800500)。

摘　　要：非洲猪瘟疫苗研发是业界公认的世界级难题。近年来,随着现代生物技术的不断发展,非洲猪瘟疫苗尤其是弱毒活疫苗的实验室研究,再次掀起新一轮热潮并取得积极进展。但是针对候选疫苗的安全性评价指标,尤其是在接种试验、怀孕母畜安全性试验、疫苗水平传播试验和毒种毒力返强试验等方面,尚没有统一的参考标准,这在一定程度上给当前的非洲猪瘟疫苗客观评价工作带来不便。本文对国内外发表文献中涉及的非洲猪瘟疫苗安全性评价部分关键指标,如疫苗接种后临床表现、水平传播能力、毒力返强能力、对怀孕母猪安全性等的研究情况进行了梳理总结,客观概述了相关研究进展以及取得的成果与存在的问题,以期为国内相关研究人员提供参考。It was recognized that development of African swine fever(ASF)vaccines was a challenge at the world level.With continuous development of modern biotechnologies,laboratory researches on ASF vaccines,especially live attenuated vaccines,had again set off a new wave with a positive progress.However,there had been no common reference standard for the safety evaluation indicators of candidate vaccines,especially in vaccination test,safety test for pregnant sows,vaccine horizontal transmission test,and virulence regression test,which compromised the objective evaluation of current ASF vaccines to a certain extent.Here,some key indicators of ASF vaccine safety evaluation,such as clinical post-vaccination performance,horizontal transmission,virulence regression as well as safety for pregnant sows involved in the papers published in China and other countries,were reviewed,and relevant research progress,achievements and problems were outlined,aiming to provide a reference for relevant researchers in China.

关 键 词：非洲猪瘟 疫苗 安全性评价 关键指标 

分 类 号：S855.3[农业科学—临床兽医学]