结核病诊断生物标志物研究进展  

Research Progress on Tuberculosis Diagnostic Biomarkers

作　　者：姜治强 刘蒙达 孙翔翔[1,3] 亓菲 南文龙 邵卫星[1] 常璐[1,4] 孙淑芳 张皓博[1,3] 樊晓旭 Jiang Zhiqiang;Liu Mengda;Sun Xiangxiang;Qi Fei;Nan Wenlong;Shao Weixing;Chang Lu;Sun Shufang;Zhang Haobo;Fan Xiaoxu(China Animal Health and Epidemiology Center,National Animal Tuberculosis Reference Laboratory,Qingdao 266032,Shandong,China;College of Veterinary Medicine,Northeast Agricultural University,Harbin 150038,Heilongjiang,China;Key Laboratory of Major Ruminant Infectious Disease Prevention andControl(East China),Ministry of Agriculture and Rural Affairs,Qingdao 266032,Shandong,China;College of Animal Technology,Shandong Agricultural University,Tai'an 271000,Shandong,China)

机构地区：[1]中国动物卫生与流行病学中心,国家动物结核病参考实验室,山东青岛266032 [2]东北农业大学动物医学学院,黑龙江哈尔滨150038 [3]农业农村部反刍动物重大疫病防控重点实验室(东部),山东青岛266032 [4]山东农业大学动物科技学院,山东泰安271000

出　　处：《中国动物检疫》2024年第10期53-62,共10页China Animal Health Inspection

基　　金：国家重点研发计划项目(2022YFD1800702);国家现代农业产业技术体系建设项目(CARS-36);青岛市科技惠民示范专项(24-1-8-xdny-4-nsh)。

摘　　要：结核病由结核分枝杆菌复合群(Mycobacterium tuberculosis complex,MTBC)引起,对全球人类和动物健康造成了较大威胁。MTBC成员基因组序列相似性较高,鉴别难度较大。而现有诊断生物标志物在结核病早期诊断、潜伏性结核分枝杆菌感染与活动性结核病状态鉴别、治疗效果评估等方面还存在不足。随着分子生物学技术的发展和临床研究的不断深入,更多新的结核病诊断生物标志物不断被发掘。本文从结核病病原和宿主两个方面,系统归纳了DNA、RNA、脂阿拉伯糖甘露聚糖(LAM)、蛋白质、细胞因子、代谢产物等结核病诊断相关生物标志物的研究进展及应用现状,以期为结核病诊断生物标志物的应用及相关诊断技术和产品的研发提供依据和方向。Tuberculosis(TB)is caused by Mycobacterium tuberculosis complex(MTBC),posing a threat to human and animal health all over the world.MTBC members have highly similar genomic sequence,resulting in difficulty in identification.But current diagnostic biomarkers are limited in early diagnosis of tuberculosis,distinguishing latent Mycobacterium tuberculosis infection from active tuberculosis status,evaluation on treatment efficacy,etc.With the development of molecular biology technologies and continuous clinical researches,more potential TB diagnostic biomarkers have been discovered.Here,the research progress and application of TB diagnostic biomarkers including DNA,RNA,lipoarabinomannan(LAM),proteins,cytokines,metabolites and others were summarized from the aspects of TB pathogens and hosts,with a view to providing a basis and direction for application of TB diagnostic biomarkers and development of relevant diagnosis technologies and products.

关 键 词：结核分枝杆菌复合群 结核病 诊断生物标志物 

分 类 号：S852.23[农业科学—基础兽医学]