拯救感染中毒症行动指南更新解读:问题与进展  

Surviving Sepsis Campaign guideline update:problems and progress

作　　者：潘盼 解立新[1] Pan Pan;Xie Lixin(College of Pulmonary and Critical Care Medicine,8th Medical Center,Chinese PLA General Hospital,Beijing 100091,China)

机构地区：[1]解放军总医院第八医学中心呼吸与危重症医学部,北京100091

出　　处：《中华结核和呼吸杂志》2024年第10期901-905,共5页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：国家自然科学基金(82341119);解放军总医院青年自主创新科研项目(22QNFC146)。

摘　　要：感染中毒症是一种临床综合征, 核心在于宿主对感染反应失调引起的机体反应紊乱所致的危及生命的器官功能不全。感染中毒症进展为感染中毒性休克可造成患者病死率升高, 因此早期识别并规范化管理尤其重要。在过去的三十年里, 感染中毒症的定义逐渐更迭, 力求提高早期感染中毒症的识别和筛查, 并强调感染中毒症患者器官功能障碍的重要性。拯救感染中毒症行动的诞生在感染中毒症患者管理中发挥了重要作用, 感染中毒症患者的集束化管理虽然降低了感染中毒性休克患者整体病死率, 但具体临床应用中仍面临许多挑战, 如何向患者提供个体化的治疗, 特别是一些有争议的治疗还有相当多的空间值得我们思考与探索。Sepsis is a clinical syndrome,the core of which is the disorder of the host′s response to infection.Sepsis progresses to septic shock,which can lead to increased mortality,so early identification and standardized management are particularly important.Over the past 30 years,the definition of septic shock has gradually changed,with efforts to improve the identification and screening of early septic shock,and to emphasize the importance of organ dysfunction in patients with septic shock.The birth of the rescue systemic infection movement has played an important role in the management of septic shock patients.Although the cluster management of septic shock patients has reduced the overall mortality of septic shock patients,the management still faces many challenges.How to provide personalized treatment to patients,especially some controversial treatments,is still a major area for us to consider and explore.

关 键 词：感染中毒性休克 感染中毒症 器官功能不全 器官功能障碍 机体反应 集束化管理 临床综合征 早期识别 

分 类 号：R459.7[医药卫生—急诊医学]