病毒感染是否可以引起感染中毒症  

Can virus infection induce sepsis?

作　　者：翁剑真 李燕明[1] Weng Jianzhen;Li Yanming(Department of Respiratory and Critical Care Medicine,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]北京医院呼吸与危重症医学科,国家老年医学中心,北京100730

出　　处：《中华结核和呼吸杂志》2024年第10期913-917,共5页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：感染中毒症是一类因宿主对感染的反应失衡而导致危及生命的器官功能障碍的临床综合征。重症病毒感染也可引起感染中毒症, 其与细菌引起的感染中毒症在病生理机制和管理策略的本质上相似, 但在细节上又略有不同。去除诱因和恢复免疫稳态是打破感染中毒症恶性循环的关键, 因此明确病原的检查手段和针对性抗感染药物的研发, 以及宿主免疫状态的动态评估(合适的生物标志物或评估模型)以及基于免疫状态的个体化免疫治疗是未来重要的研究方向。Sepsis is a clinical syndrome caused by a dysregulated host response to infection that can lead to multiple organ dysfunction syndrome and death.Severe viral infections can also induce sepsis,which is essentially similar to bacterial sepsis in physiological mechanism and management strategies,but slightly different in detail.Anti-microbial treatment and restoration of immune homeostasis are key to breaking the vicious circle of sepsis.Therefore,it is important to develop more accurate and convenient measures for pathogen detection and research into targeted anti-microbial agents,as well as to explore ways of evaluating the dynamic immune status of host and individualized immunotherapies based on immune status.

关 键 词：病毒感染 宿主免疫 抗感染药物 免疫治疗 器官功能障碍 生物标志物 临床综合征 动态评估 

分 类 号：R459.7[医药卫生—急诊医学]