衰老相关分泌表型在特发性肺纤维化中的研究进展  

Research progress on senescence-associated secretory phenotypes in idiopathic pulmonary fibrosis

作　　者：胡莉娟 刘若雨 周允[2] 曹永彤[2] Hu Lijuan;Liu Ruoyu;Zhou Yun;Cao Yongtong(Graduate School of Chinese Academy of Medical Sciences,Beijing 100730 China;China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京协和医学院研究生院,北京100730 [2]中日友好医院检验科,北京100029

出　　处：《中华检验医学杂志》2024年第10期1215-1224,共10页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金(82272407,82072337)。

摘　　要：特发性肺纤维化(IPF)是多发生于中老年人的间质性肺病,中位生存期短,无法治愈,病因尚不清楚,目前认为其发病机制与细胞衰老有关,异常的细胞衰老导致受损的肺泡上皮细胞不能正常修复,促进了肺纤维化的发生,而衰老的细胞分泌特征性蛋白质,称为衰老相关分泌表型(SASP)。SASP通过不同信号通路在IPF患者肺纤维化过程发挥重要作用,因此研究SASP在IPF患者体内的表达水平和作用机制至关重要。Idiopathic pulmonary fibrosis(IPF)is an interstitial lung disease that occurs mostly in the middle-aged and eldly people,with a short median survival and cannot be cured,and the etiology is still unclear.Currently,it is believed that the pathogenesis is related to cellular aging,and abnormal cellular aging leads to the failure of damaged alveolar epithelial cells that cannot be repaired normally,which promotes the occurrence of pulmonary fibrosis.Senescence-associated secretory phenotype(SASP),SASP affects pulmonary fibrosis through different signaling pathways in IPF patients,and this article reviews the expression level and mechanism of existing SASP in IPF patients.

关 键 词：肺纤维化 特发性肺纤维化 衰老相关分泌表型 衰老 生物标志物 

分 类 号：R563[医药卫生—呼吸系统]