血清S100A8/A9与急性心肌梗死患者PCI术后主要不良心血管事件的关系  

Relationship between serum S100A8/A9 andmajor adverse cardiovascular eventsin patients with acute myocardial infarctionafter percutaneous coronary intervention

作　　者：张伟健 刘一辰 闫瑶 赵传艳[2] Zhang Weijian;Liu Yichen;Yan Yao;Zhao Chuanyan(School of Clinical Medicine,Shandong Second Medical University,Weifang 261000,China;不详)

机构地区：[1]山东第二医科大学临床医学院,潍坊261000 [2]潍坊市益都中心医院心内科,潍坊262500

出　　处：《中国循证心血管医学杂志》2024年第9期1092-1095,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：山东省医药卫生科技发展计划项目(202003240812);潍坊市科技发展计划项目(2022YX117)。

摘　　要：目的探究血清S100钙结合蛋白A8/A9复合物(S100A8/A9)水平对急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后主要不良心血管事件(MACE)的预测价值。方法选取2019年3月至2020年12月于山东第二医科大学临床医学院进行PCI的193例AMI患者为AMI组,根据PCI术后在1月内是否发生MACE分为MACE组(n=25)和未MACE组(n=168),另选取同时我院体检的健康志愿者201例为对照组。采用ELISA法检测受试者血清S100A8/A9水平,分析AMI患者PCI术后1月内MACE的影响因素,采用ROC曲线评估血清S100A8/A9对AMI患者PCI术后发生MACE的预测价值;MACE情况的影响因素通过Logistic回归分析进行。结果与对照组比较,AMI组患者血清S100A8/A9水平显著升高(P<0.05);MACE组患者合并高血脂症、冠状动脉粥样硬化性心脏病(冠心病)、空腹血糖(FBG)、三酰甘油(TG)、总胆固醇(TC)、植入支架数目≥2个、支架直径≥3mm的比例以及心率均高于未MACE组(P<0.05);与未MACE组比较,发生MACE组患者血清S100A8/A9水平显著升高(P<0.05);ROC曲线结果确定,S100A8/A9的评估价值为0.699,当S100A8/A9>3.158 mg/ml时,可预测AMI患者PCI术后MACE的发生,灵敏度为65.7%,特异性为65.9%,Logistic回归分析结果确定,S100A8/A9是MACE的显著危险因素。结论血清S100A8/A9水平与AMI患者PCI术后MACE的发生有关,检测血清S100A8/A9水平可能有助于判断AMI患者PCI术后MACE情况。Objective To investigate the predictive value of serum S100A8/A9 to major adverse cardiovascular events(MACE)in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods AMI patients undergone PCI(n=193)were chosen into AMI group from School of Clinical Medicine of Shandong Second Medical University from Mar.2019 to Dec.2020.According to whether MACE occurred within 1 month after PCI or not,the AMI group was divided into MACE group(n=25)and non-MACE group(n=168),and healthy volunteers with physical examination(n=201)were chosen into control during the same period.The level of serum S100A8/A9 was detected by using ELISA,and influence factors for MACE occurrence within 1 month after PCI were analyzed.The predictive value of S100A8/A9 to MACE occurrence after PCI was reviewed by using ROC curve analysis.The influence factors for MACE occurrence were analysis by using Logistic regression analysis.Results The level of S100A8/A9 increased significantly in AMI group compared with control group(P<0.05).The number of AMI patients complicated by hyperlipidemia and coronary heart disease(CHD),levels of fasting blood glucose(FBG),triglyceride(TG)and total cholesterol(TC),number of implanted stents≥2,stent diameter≥3 mm and heart rate(HR)were all higher in MACE group than those in non-MACE group(P<0.05).The level of S100A8/A9 increased significantly in MACE group than that in non-MACE group(P<0.05).The results of ROC curve analysis showed that the review value of S100A8/A9 was 0.699,and when S100A8/A9>3.158 mg/ml,it could predict MACE after PCI,and sensitivity was 65.7%and specificity was 65.9%.The results of Logistic regression analysis showed that S100A8/A9 was a significant risk factor for MACE occurrence in AMI patients.Conclusion The level of serum S100A8/A9 is correlated to MACE occurrence,and detection of S100A8/A9may help determine MACE status in AMI patients after PCI.

关 键 词：急性心肌梗死 经皮冠状动脉介入治疗 主要不良心血管事件 

分 类 号：R542.22[医药卫生—心血管疾病]