SII、PLR及MLR与急性冠状动脉综合征PCI术后主要不良心血管事件发生风险的相关性分析  

Correlation analysis of SII,PLR and MLR with risk of major adverse cardiovascular events in acute coronary syndrome after PCI

作　　者：朱晓飞 丁志成 王海明 Zhu Xiaofei;Ding Zhicheng;Wang Haiming(Department of Critical Care Medicine,Chinese Medicine Hospital of Puyang,Puyang 457000,Henan,China;不详)

机构地区：[1]濮阳市中医医院重症医学科,濮阳457000

出　　处：《中国循证心血管医学杂志》2024年第9期1128-1131,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探究系统免疫炎性指数(SII)、血小板与淋巴细胞比值(PLR)及单核细胞与淋巴细胞比值(MLR)与急性冠状动脉综合征经皮冠脉介入治疗(PCI)术后主要不良心血管事件发生风险的相关性。方法回顾性分析2021年1月至2022年1月于濮阳市中医医院重症医学科行PCI的87例急性冠脉综合征患者,入院次日检测患者血小板、中性粒细胞、淋巴细胞以及单核细胞水平,计算患者SII、PLR、MLR水平,随访12个月,将出现不良心血管事件的21例患者作为预后不良组,未出现不良心血管事件的66例患者作为预后良好组,比较两组患者的临床资料;评估SII、PLR及MLR对患者预后的预测价值。结果87例急性冠状动脉综合征患者PCI术后不良心血管事件的发生率为24.14%;预后不良组肌酸激酶同工酶(CK-MB)、脑钠肽(BNP)、血小板计数、中性粒细胞计数、单核细胞计数均高于预后良好组,淋巴细胞计数低于预后良好组(P<0.05);预后不良组SII、PLR、MLR均高于预后良好组(P<0.05);高SII、PLR及MLR是急性冠状动脉综合征患者PCI术后发生不良心血管事件的独立危险因素(P<0.05);SII预测急性冠状动脉综合征患者PCI术后发生不良心血管事件的价值最高,约登指数最大时,曲线下面积(AUC)为0.732,对应临界值为618.83(×109/L),敏感度和特异度分别为71.43%和72.73%。结论SII、PLR及MLR对急性冠状动脉综合征PCI术后发生主要不良心血管事件具有良好的预测价值,为患者临床治疗提供一定指导作用。Objective To explore the correlation between systemic immune-inflammatory index(SII),platelet-to-lymphocyte ratio(PLR),and monocyte-to-lymphocyte ratio(MLR)and the risk of major adverse cardiovascular events in acute coronary syndrome after percutaneous coronary intervention(PCI).Methods A retrospective analysis was performed on 87 patients with acute coronary syndrome who underwent PCI in the Department of Critical Care Medicine of Chinese Medicine Hospital of Puyang from January 2021 to January 2022.The levels of platelet,neutrophil,lymphocyte and monocyte were detected on the next day after admission,and the levels of SII,PLR and MLR were calculated.The patients were followed up for 12 months.21 patients with adverse cardiovascular events were enrolled in the poor prognosis group,and 66 patients without adverse cardiovascular events were included in the good prognosis group.The clinical data of the two groups were compared,and the predictive value of SII,PLR and MLR on prognosis of patients was evaluated.Results The incidence rate of adverse cardiovascular events after PCI in 87 patients with acute coronary syndrome was 24.14%.Creatine kinase isoenzyme(CK-MB),B-type natriuretic peptide(BNP),platelet count,neutrophil count,and monocyte count in the poor prognosis group were higher than those in the good prognosis group,while lymphocyte count was lower than that in the good prognosis group(P<0.05).SII,PLR,and MLR were higher in the poor prognosis group than in the good prognosis group(P<0.05).High SII,PLR and MLR were independent risk factors of adverse cardiovascular events in patients with acute coronary syndrome after PCI(P<0.05).The value of SII on predicting adverse cardiovascular events after PCI in patients with acute coronary syndrome was the highest.When the Youden index was the largest,the area under the curve(AUC),corresponding critical value,sensitivity and specificity were 0.732,618.83(×109/L),71.43%and 72.73%respectively.Conclusion SII,PLR and MLR have good predictive value on major adverse cardio

关 键 词：急性冠状动脉综合征 系统免疫炎性指数 血小板与淋巴细胞比值 单核细胞与淋巴细胞比值 经皮冠脉介入术 不良心血管事件 

分 类 号：R541.4[医药卫生—心血管疾病]