基于气络学说探讨活血法在调控肿瘤免疫、抗肿瘤转移中的应用  

Exploring the Application of Regulating Tumour Immunity and Anti-tumour Metastasis by Invigorating Blood Method Based on the Theory of Qi Channels

作　　者：王菁 张培彤[2] 缪锐[1,2] 张若琪 何杰 WANG Jing;ZHANG Peitong;MIAO Rui;ZHANG Ruoqi;HE Jie(Graduate School,Beijing University of Chinese Medicine,Beijing,100029;Guang'anmen Hospital,China Academy of Chinese Medical Sciences;Women and Children's Hospital,School of Medicine,Xiamen University)

机构地区：[1]北京中医药大学研究生院,北京市100029 [2]中国中医科学院广安门医院 [3]厦门大学附属妇女儿童医院

出　　处：《中医杂志》2024年第20期2163-2165,2172,共4页Journal of Traditional Chinese Medicine

基　　金：北京市自然科学基金(7232312)。

摘　　要：基于气络学说探讨活血法在调控肿瘤免疫中的应用,为中医药调控肿瘤免疫、抗肿瘤转移提供思路与方法。认为气络与肿瘤免疫密切相关,气络相当于肿瘤免疫微环境中具有抗肿瘤作用的免疫网络,包括免疫细胞及免疫因子等。结合气络的生理功能和病理特点,提出气络为病的病机为气络失司、瘀血阻滞,气络虚滞是发生肿瘤免疫抑制、促肿瘤转移的基础,气络郁滞是发生肿瘤免疫抑制、促肿瘤转移的条件。针对气络失司致肿瘤免疫抑制的病机,提出活血法调节气络以调控肿瘤免疫的治疗原则为“以通为用,以平为期”,治疗关键在于调衡气络、通络祛瘀。According to the theory of qi channels,we explored the relationship of the method of invigorating blood and regulating tumour immunity,to provide ideas and methods for traditional Chinese medicine for regulating tumour immunity and anti-tumour metastasis.It is believed that qi channels are closely related to tumour immunity,and qi channels are equivalent to immune networks such as immune cells and immune factors with anti-tumour immunity in the tumour immune micro-environment.Combined with the physiological function and pathological characteristics of qi channels,it is proposed that the pathogenesis of qi channels-related disease due to qi channels failing to govern,blood stasis obstructing,and qi channels deficiency and stagnation as the basis for the occurrence of tumour immunosuppression and metastasis,and that qi channels constraint and stagnation as the condition for the occurrence of tumour immunosuppression and metastasis.In view of the pathomechanism of tumour immune escape caused by qi channels failing to govern,it is proposed that the therapeutic principle of regulating qi and channels to regulate tumour immunity by invigorating blood circulation method could be"per⁃forming functions when there is free flow,reaching the expectation when balanced",and the key of treatment is to regulate qi and channels,unblock the collaterals to dispel stasis.

关 键 词：肿瘤转移 免疫抑制 气络 活血 

分 类 号：R273[医药卫生—中西医结合]