Highly oxygenated clerodane furanoditerpenoids from the leaves and twigs of Croton yunnanensis  

作　　者：WANG Didi MEI Fang NIE Jinchun LI Zhenwei ZHANG Daidi GUO Dean LI Wei 

机构地区：[1]School of Pharmacy,Guizhou Medical University,Guiyang 550025,China [2]Zhongshan Institute for Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Zhongshan 528400,China

出　　处：《Chinese Journal of Natural Medicines》2024年第10期945-954,共10页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.82104020 and 82130111);the High-level Innovative Research Institute of Department of Science and Technology of Guangdong Province(No.2021B0909050003);the High-level New R&D Institute of Department of Science and Technology of Guangdong Province(No.2019B090904008)。

摘　　要：The phytochemical investigation of the leaves and twigs of Croton yunnanensis resulted in the isolation of eight new clerodane furanoditerpenoids,named croyunfuranoids A-H(1-8),along with three known analogs(9-11).The structures of these compounds were elucidated using spectroscopic analyses,and their absolute configurations were determined through a combination of electronic circular dichroism(ECD)calculations and single-crystal X-ray diffraction.Notably,Croyunfuranoid D(4)is identified as a rare 18,19-dinor-clerodane diterpenoid.Additionally,the structure of a previously reported diterpenoid,crotonyunnan B,was revised.All isolated compounds were evaluated for their inhibitory activities on nitric oxide(NO)production in LPS-induced RAW 264.7 macrophages.Among them,compounds 5 and 6 demonstrated significant inhibitory effects,with IC_(50)values of 20.33±2.31 and 22.80±1.31μmol·L^(-1),respectively.

关 键 词：Croton yunnanensis EUPHORBIACEAE Clerodane furanoditerpenoid NO inhibitory activity 

分 类 号：R284.1[医药卫生—中药学]